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Gene Review:

Slc23a1 - solute carrier family 23 (nucleobase...

Mus musculus

Synonyms: D18Ucla2, Na(+)/L-ascorbic acid transporter 1, SVCT1, Slc23a2, Sodium-dependent vitamin C transporter 1, ...

Kuo, S.M. et al., Qiu, S. et al., Fujita, I. et al., Wu, X. et al., García, M.d.e. .L. et al.

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High impact information on Slc23a1

Recently, two different isoforms of sodium-vitamin C cotransporters (SVCT1/SLC23A1 and SVCT2/SLC23A2) have been cloned [1].
Neurons maintain relatively high intracellular concentrations of ascorbic acid, which is achieved primarily by the activity of the sodium-dependent vitamin C transporter SVCT2 [2].
Sodium-dependent vitamin C transporter (SVCT) 2 facilitates reduced ascorbic acid (AA) transport in MC3T3-E1 osteoblasts [3].
The present study investigates AsA uptake and expression of Na-dependent vitamin C transporter (SVCT) mRNA in the mouse osteoblastic cell line, MC3T3-E1 [4].

Anatomical context of Slc23a1

RT-PCR analysis showed that liver and kidney expressed mainly SVCT1, and brain, skeletal muscle, and spleen expressed predominantly SVCT2 [5].

Associations of Slc23a1 with chemical compounds

Compared with males, females had lower ascorbate excretion and ascorbate:creatinine ratio in urine and had higher ascorbate concentrations in plasma and SVCT1-predominant tissues [5].

Other interactions of Slc23a1

Additionally, lower ascorbate excretion in females may elevate the vitamin's concentrations in plasma and tissues expressing SVCT1 that, unlike SVCT2, is not saturated by plasma ascorbate concentrations [5].

References

Sodium vitamin C cotransporter SVCT2 is expressed in hypothalamic glial cells. García, M.d.e. .L., Salazar, K., Millán, C., Rodríguez, F., Montecinos, H., Caprile, T., Silva, C., Cortes, C., Reinicke, K., Vera, J.C., Aguayo, L.G., Olate, J., Molina, B., Nualart, F. Glia (2005) [Pubmed]
Ascorbate transport by primary cultured neurons and its role in neuronal function and protection against excitotoxicity. Qiu, S., Li, L., Weeber, E.J., May, J.M. J. Neurosci. Res. (2007) [Pubmed]
Stimulation of differentiation in sodium-dependent vitamin C transporter 2 overexpressing MC3T3-E1 osteoblasts. Wu, X., Itoh, N., Taniguchi, T., Hirano, J., Nakanishi, T., Tanaka, K. Biochem. Biophys. Res. Commun. (2004) [Pubmed]
Dexamethasone induces sodium-dependant vitamin C transporter in a mouse osteoblastic cell line MC3T3-E1. Fujita, I., Hirano, J., Itoh, N., Nakanishi, T., Tanaka, K. Br. J. Nutr. (2001) [Pubmed]
Gender and sodium-ascorbate transporter isoforms determine ascorbate concentrations in mice. Kuo, S.M., MacLean, M.E., McCormick, K., Wilson, J.X. J. Nutr. (2004) [Pubmed]

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