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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

Slc34a2  -  solute carrier family 34 (sodium...

Mus musculus

Synonyms: AA536683, D5Ertd227e, Na(+)-dependent phosphate cotransporter 2B, Na(+)/Pi cotransporter 2B, NaPi-2b, ...
 
 
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High impact information on Slc34a2

  • Quantitative RT-PCR analyses revealed that the amount of Npt2b mRNA, an isoform of Npt2, in Hyp mouse tooth germs was significantly lower than that in wild-type mice, in both in vivo and in vitro experiments [1].
  • In addition, tooth germs from wild-type mice cultured in medium supplemented with antisense oligo-deoxynucleotide for Phex also showed a reduction of Npt2b mRNA expression [1].
  • The presence of NaPi-2a and NaPi-2b, gene products of Npt-2a and Npt-2b, was verified in vivo by immunohistochemistry on mouse teeth [2].

References

  1. Phex mutation causes the reduction of npt2b mRNA in teeth. Onishi, T., Okawa, R., Ogawa, T., Shintani, S., Ooshima, T. J. Dent. Res. (2007) [Pubmed]
  2. Odontoblast phosphate and calcium transport in dentinogenesis. Lundquist, P. Swedish dental journal. Supplement. (2002) [Pubmed]
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