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Gene Review:

SLC34A2 - solute carrier family 34 (type II...

Homo sapiens

Synonyms: NAPI-3B, NAPI-IIb, NPTIIb, Na(+)-dependent phosphate cotransporter 2B, Na(+)/Pi cotransporter 2B, ...

Corut, A. et al., Murer, H. et al., Xu, H. et al., Rangel, L.B. et al.

Murer, Forster, Biber,

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High impact information on SLC34A2

We first identified a PAM locus by homozygosity mapping to 4p15, then identified, by a candidate-gene approach, the gene responsible for the disease as SLC34A2 (the type IIb sodium-phosphate cotransporter gene), which is involved in phosphate homeostasis in several organs [1].
The sodium-dependent phosphate transporter (HOST5/SLC34A2) expression was associated with increased differentiation in ovarian serous tumors [2].
Molecular cloning, functional characterization, tissue distribution, and chromosomal localization of a human, small intestinal sodium-phosphate (Na+-Pi) transporter (SLC34A2) [3].
This review summarizes the characteristics of the solute carrier family SLC34 that is represented by the type ll Na/P(i)-cotransporters NaPi-lla (SLC34A1), NaPi-llb (SLC34A2) and NaPi-llc (SLC34A3) [4].

References

Mutations in SLC34A2 Cause Pulmonary Alveolar Microlithiasis and Are Possibly Associated with Testicular Microlithiasis. Corut, A., Senyigit, A., Ugur, S.A., Altin, S., Ozcelik, U., Calisir, H., Yildirim, Z., Gocmen, A., Tolun, A. Am. J. Hum. Genet. (2006) [Pubmed]
Characterization of novel human ovarian cancer-specific transcripts (HOSTs) identified by serial analysis of gene expression. Rangel, L.B., Sherman-Baust, C.A., Wernyj, R.P., Schwartz, D.R., Cho, K.R., Morin, P.J. Oncogene (2003) [Pubmed]
Molecular cloning, functional characterization, tissue distribution, and chromosomal localization of a human, small intestinal sodium-phosphate (Na+-Pi) transporter (SLC34A2). Xu, H., Bai, L., Collins, J.F., Ghishan, F.K. Genomics (1999) [Pubmed]
The sodium phosphate cotransporter family SLC34. Murer, H., Forster, I., Biber, J. Pflugers Arch. (2004) [Pubmed]

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