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Gene Review:

Stau1 - staufen (RNA binding protein) homolog 1...

Mus musculus

Synonyms: 5830401L18Rik, AW549911, C85792, Double-stranded RNA-binding protein Staufen homolog 1, Stau

Bélanger, G. et al.

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High impact information on Stau1

Immunofluorescence experiments revealed that Staufen1 (Stau1) and Staufen2 (Stau2) accumulate preferentially within the postsynaptic sarcoplasm of muscle fibers as well as at newly formed ectopic synapses [1].

Anatomical context of Stau1

We propose that Stau1 and Stau2 are key components of the postsynaptic apparatus in muscle, and that they contribute to the maturation and plasticity of the neuromuscular junction [1].

Analytical, diagnostic and therapeutic context of Stau1

Western blot analyses showed that the levels of Stau1 and Stau2 are greater in slow muscles than in fast-twitch muscles [1].
Muscle denervation induced a significant increase in the expression of Stau1 and Stau2 in the extrasynaptic compartment of both fast and slow muscles [1].

References

Localization of the RNA-binding proteins Staufen1 and Staufen2 at the mammalian neuromuscular junction. Bélanger, G., Stocksley, M.A., Vandromme, M., Schaeffer, L., Furic, L., DesGroseillers, L., Jasmin, B.J. J. Neurochem. (2003) [Pubmed]

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STAU1	Homo sapiens
STAU1	Macaca mulatta
STAU1	Pan troglodytes
Stau1	Rattus norvegicus

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