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Gene Review

STAU1  -  staufen double-stranded RNA binding protein 1

Homo sapiens

Synonyms: Double-stranded RNA-binding protein Staufen homolog 1, PPP1R150, STAU
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Disease relevance of STAU1


High impact information on STAU1

  • Here we describe an mRNA decay mechanism that involves Stau1, the NMD factor Upf1, and a termination codon [2].
  • Immunofluorescent double labeling of transfected mammalian cells revealed that Stau is localized to the rough endoplasmic reticulum (RER), implicating this RNA-binding protein in mRNA targeting to the RER, perhaps via a multistep process involving microtubules [3].
  • Although Stau2 has many features in common with its paralogue Stau1, it does not colocalize with Stau1-containing particles, indicating that these proteins are components of different complexes in dendrites [4].
  • Apart from those three exons, the overall organization of the stau gene is similar in the two species, and the positions of the exon-intron junctions are perfectly conserved [5].
  • However, Stau1 nuclear transit seems to be regulated by mechanisms that involve cytoplasmic retention and/or facilitated nuclear export [6].

Anatomical context of STAU1


Physical interactions of STAU1

  • SMD depends on the recruitment of Upf1 by the RNA-binding protein Stau1 but does not depend on the other Upf proteins [7].

Analytical, diagnostic and therapeutic context of STAU1


  1. Suppression of the tumorigenicity of prostatic cancer cells by gene(s) located on human chromosome 19p13.1-13.2. Gao, A.C., Lou, W., Ichikawa, T., Denmeade, S.R., Barrett, J.C., Isaacs, J.T. Prostate (1999) [Pubmed]
  2. Mammalian Staufen1 recruits Upf1 to specific mRNA 3'UTRs so as to elicit mRNA decay. Kim, Y.K., Furic, L., Desgroseillers, L., Maquat, L.E. Cell (2005) [Pubmed]
  3. Mammalian staufen is a double-stranded-RNA- and tubulin-binding protein which localizes to the rough endoplasmic reticulum. Wickham, L., Duchaîne, T., Luo, M., Nabi, I.R., DesGroseillers, L. Mol. Cell. Biol. (1999) [Pubmed]
  4. Staufen2 isoforms localize to the somatodendritic domain of neurons and interact with different organelles. Duchaîne, T.F., Hemraj, I., Furic, L., Deitinghoff, A., Kiebler, M.A., DesGroseillers, L. J. Cell. Sci. (2002) [Pubmed]
  5. Genomic organization of the human and mouse stau genes. Brizard, F., Luo, M., Desgroseillers, L. DNA Cell Biol. (2000) [Pubmed]
  6. Staufen1 is imported into the nucleolus via a bipartite nuclear localization signal and several modulatory determinants. Martel, C., Macchi, P., Furic, L., Kiebler, M.A., Desgroseillers, L. Biochem. J. (2006) [Pubmed]
  7. CBP80 promotes interaction of Upf1 with Upf2 during nonsense-mediated mRNA decay in mammalian cells. Hosoda, N., Kim, Y.K., Lejeune, F., Maquat, L.E. Nat. Struct. Mol. Biol. (2005) [Pubmed]
  8. Localization of a human double-stranded RNA-binding protein gene (STAU) to band 20q13.1 by fluorescence in situ hybridization. DesGroseillers, L., Lemieux, N. Genomics (1996) [Pubmed]
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