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Gene Review:

T(2;4)1Go - reciprocal translocation, Chr 2 and 4,...

Mus musculus

Synonyms: T1Go

Beermann, F. et al., Tease, C., Peters, J. et al.

Tease,

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High impact information on T(2;4)1Go

For T(2;4)1Go, the sex-related difference in segregation patterns resulted in a diminished expectation of genetically imbalanced gametes, although this was not the case for T(7;16)67H [1].
Chromosome segregation at meiosis I in female T(2;4)1Gö/+ mice: no evidence for a decreased crossover frequency with maternal age [2].
We have shown that T2Wa and T(2;4)1Go, (T1Go), which has a breakpoint in central H3 map close to a, non-agouti [3].

Biological context of T(2;4)1Go

For both the large 2(4) and the small 4(2) marker chromosomes, this frequency was higher in old than in young T(2;4)1Gö/+ females [2].

References

Chiasma distributions and chromosome segregation in male and female translocation heterozygous mice analysed using FISH. Tease, C. Chromosoma (1998) [Pubmed]
Chromosome segregation at meiosis I in female T(2;4)1Gö/+ mice: no evidence for a decreased crossover frequency with maternal age. Beermann, F., Bartels, I., Franke, U., Hansmann, I. Chromosoma (1987) [Pubmed]
Mapping studies of the distal imprinting region of mouse chromosome 2. Peters, J., Beechey, C.V., Ball, S.T., Evans, E.P. Genet. Res. (1994) [Pubmed]

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