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Gene Review

T(2;8)26H  -  reciprocal translocation, Chr 2 and 8,...

Mus musculus

Synonyms: T(5;18)26H, T26H
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High impact information on T(2;8)26H

  • More detailed mapping analysis of Nnat showed that it is located between the T26H and T2Wa translocation breakpoints which is, surprisingly, proximal to the reported imprinting region between the T2Wa and T28H translocation breakpoints, suggesting that there may be two distinct imprinting regions on distal chromosome 2 [1].
  • Of the T70H/T1Wa double heterozygotes, 36% of the males are capable of inducing at least one decidual reaction in two females whereas for T26H/T2Wa, 79% of the males can do so [2].
  • Mean testis weights were significantly reduced on the C57BL background with all four translocations as compared to wild-type, but also significantly increased in T26H on CBA [3].
  • Male meiotic behaviour and male and female litter size in mice with the T(2;8)26H and T(1;13)70H reciprocal translocations [4].
  • The translocation breakpoints of T(2;8)26H are mapped at 73% and 45% from the telocentric centromeres of chromosomes 2 and 8, while those of T(9;17)138Ca are mapped at 41% and 45% from the telocentric centromeres of chromosomes 9 and 17 respectively [5].

Biological context of T(2;8)26H

  • To investigate the potential role of Nnat, we compared normal embryos with those which were PatDp.dist2.T26H (paternal duplication/maternal deficiency of chromosome 2 distal to the translocation breakpoint T26H) and MatDp.dist2.T26H [1].

Anatomical context of T(2;8)26H

  • Three dimensional reconstruction from electron micrographs of serial sections reveals 18 synaptonemal complexes and a cross-shaped quadrivalent in the mouse pachytene oocytes of the heterozygous reciprocal translocations T(2;8)26H and T(9;17)138Ca [5].


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