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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

ETV2  -  ets variant 2

Homo sapiens

Synonyms: ER71, ETS translocation variant 2, ETSRP71, Ets-related protein 71
 
 
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High impact information on ETV2

  • ER81 and GABP alpha were present in most tissues of adult mice, whereas ER71 was restricted to testis [1].
  • GABP alpha, ER71, and ER81 recognized the common pentanucleotide DNA sequence 5'-CGGAA/T-3'. Although subtle differences were observed for nucleotide preferences flanking this pentanucleotide core, the overall similarity of the selected sequences was most striking [1].
  • Furthermore, two ER71 isoforms exist that differ by 22 N-terminal amino acids, but show no difference in DNA binding or transactivation [2].
  • Thus, TSGA may modulate the function of ER71 and thereby affect spermatogenesis as well as embryonic development [3].
  • Altogether, these data represent the first functional characterization of ER71, which may perform important functions in the developing and adult testis as well as in testicular germ cell tumorigenesis [4].

References

  1. Specificities of protein-protein and protein-DNA interaction of GABP alpha and two newly defined ets-related proteins. Brown, T.A., McKnight, S.L. Genes Dev. (1992) [Pubmed]
  2. Cloning of the murine ER71 gene (Etsrp71) and initial characterization of its promoter. De Haro, L., Janknecht, R. Genomics (2005) [Pubmed]
  3. Repression of transcription by TSGA/Jmjd1a, a novel interaction partner of the ETS protein ER71. Knebel, J., De Haro, L., Janknecht, R. J. Cell. Biochem. (2006) [Pubmed]
  4. Functional analysis of the transcription factor ER71 and its activation of the matrix metalloproteinase-1 promoter. De Haro, L., Janknecht, R. Nucleic Acids Res. (2002) [Pubmed]
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