Gene Review:
EXTL2 - exostosin-like glycosyltransferase 2
Homo sapiens
Synonyms:
Alpha-1,4-N-acetylhexosaminyltransferase EXTL2, Alpha-GalNAcT EXTL2, EXT-related protein 2, EXTR2, Exostosin-like 2, ...
- Human tumor suppressor EXT gene family members EXTL1 and EXTL3 encode alpha 1,4- N-acetylglucosaminyltransferases that likely are involved in heparan sulfate/ heparin biosynthesis. Kim, B.T., Kitagawa, H., Tamura , J., Saito, T., Kusche-Gullberg, M., Lindahl, U., Sugahara, K. Proc. Natl. Acad. Sci. U.S.A. (2001)
- The tumor suppressor EXT-like gene EXTL2 encodes an alpha1, 4-N-acetylhexosaminyltransferase that transfers N-acetylgalactosamine and N-acetylglucosamine to the common glycosaminoglycan-protein linkage region. The key enzyme for the chain initiation of heparan sulfate. Kitagawa, H., Shimakawa, H., Sugahara, K. J. Biol. Chem. (1999)
- Identification and characterization of a novel member of the EXT gene family, EXTL2. Wuyts, W., Van Hul, W., Hendrickx, J., Speleman, F., Wauters, J., De Boulle, K., Van Roy, N., Van Agtmael, T., Bossuyt, P., Willems, P.J. Eur. J. Hum. Genet. (1997)
- Characterization of Specific Donor Binding to alpha1,4-N-Acetylhexosaminyltransferase EXTL2 Using Isothermal Titration Calorimetry. Sobhany, M., Negishi, M. Meth. Enzymol. (2006)
- Characterization and genomic localization of the mouse Extl2 gene. Wuyts, W., Van Hul, W. Cytogenet. Cell Genet. (2000)
- Mutation analysis of hereditary multiple exostoses in the Chinese. Xu, L., Xia, J., Jiang, H., Zhou, J., Li, H., Wang, D., Pan, Q., Long, Z., Fan, C., Deng, H.X. Hum. Genet. (1999)
