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Gene Review

EXTL2  -  exostosin-like glycosyltransferase 2

Homo sapiens

Synonyms: Alpha-1,4-N-acetylhexosaminyltransferase EXTL2, Alpha-GalNAcT EXTL2, EXT-related protein 2, EXTR2, Exostosin-like 2, ...
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High impact information on EXTL2


Associations of EXTL2 with chemical compounds

  • Human EXTL2 is an alpha1,4-N-acetylhexosaminyltransferase involved in the biosynthesis of heparin/heparan sulfate [5].

Other interactions of EXTL2

  • No disease-related mutation has been found in either EXTL1 or EXTL2, although one polymorphism has been detected in EXTL1 [6].

Analytical, diagnostic and therapeutic context of EXTL2

  • Characterization of Specific Donor Binding to alpha1,4-N-Acetylhexosaminyltransferase EXTL2 Using Isothermal Titration Calorimetry [4].


  1. Human tumor suppressor EXT gene family members EXTL1 and EXTL3 encode alpha 1,4- N-acetylglucosaminyltransferases that likely are involved in heparan sulfate/ heparin biosynthesis. Kim, B.T., Kitagawa, H., Tamura , J., Saito, T., Kusche-Gullberg, M., Lindahl, U., Sugahara, K. Proc. Natl. Acad. Sci. U.S.A. (2001) [Pubmed]
  2. The tumor suppressor EXT-like gene EXTL2 encodes an alpha1, 4-N-acetylhexosaminyltransferase that transfers N-acetylgalactosamine and N-acetylglucosamine to the common glycosaminoglycan-protein linkage region. The key enzyme for the chain initiation of heparan sulfate. Kitagawa, H., Shimakawa, H., Sugahara, K. J. Biol. Chem. (1999) [Pubmed]
  3. Identification and characterization of a novel member of the EXT gene family, EXTL2. Wuyts, W., Van Hul, W., Hendrickx, J., Speleman, F., Wauters, J., De Boulle, K., Van Roy, N., Van Agtmael, T., Bossuyt, P., Willems, P.J. Eur. J. Hum. Genet. (1997) [Pubmed]
  4. Characterization of Specific Donor Binding to alpha1,4-N-Acetylhexosaminyltransferase EXTL2 Using Isothermal Titration Calorimetry. Sobhany, M., Negishi, M. Meth. Enzymol. (2006) [Pubmed]
  5. Characterization and genomic localization of the mouse Extl2 gene. Wuyts, W., Van Hul, W. Cytogenet. Cell Genet. (2000) [Pubmed]
  6. Mutation analysis of hereditary multiple exostoses in the Chinese. Xu, L., Xia, J., Jiang, H., Zhou, J., Li, H., Wang, D., Pan, Q., Long, Z., Fan, C., Deng, H.X. Hum. Genet. (1999) [Pubmed]
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