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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

Tfeb  -  transcription factor EB

Mus musculus

Synonyms: TFEB, Tcfeb, Transcription factor EB, bHLHe35
 
 
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High impact information on Tcfeb

  • Mutational studies in mice have shown that Mitf is essential for melanocyte and eye development, whereas Tfeb is required for placental vascularization [1].
  • The expression of several trophoblast markers was also altered, including an increase in the spongiotrophoblast marker Mash2 and decreases in the labyrinthine markers Tfeb and Gcm1 [2].
  • Our results indicate that Tfeb plays a critical role in the signal transduction processes required for normal vascularization of the placenta [3].
  • Here we show that mice with a targeted disruption of Tfeb die between 9.5 and 10.5 days in embryonic development and have severe defects in placental vascularization [3].
 

Anatomical context of Tcfeb

  • Tfeb is expressed at low levels in the embryo but at high levels in the labyrinthine trophoblast cells of the placenta [3].
 

Physical interactions of Tcfeb

References

  1. Mitf and Tfe3, two members of the Mitf-Tfe family of bHLH-Zip transcription factors, have important but functionally redundant roles in osteoclast development. Steingrimsson, E., Tessarollo, L., Pathak, B., Hou, L., Arnheiter, H., Copeland, N.G., Jenkins, N.A. Proc. Natl. Acad. Sci. U.S.A. (2002) [Pubmed]
  2. Placental but Not Heart Defects Are Associated with Elevated Hypoxia-Inducible Factor {alpha} Levels in Mice Lacking Prolyl Hydroxylase Domain Protein 2. Takeda, K., Ho, V.C., Takeda, H., Duan, L.J., Nagy, A., Fong, G.H. Mol. Cell. Biol. (2006) [Pubmed]
  3. The bHLH-Zip transcription factor Tfeb is essential for placental vascularization. Steingrímsson, E., Tessarollo, L., Reid, S.W., Jenkins, N.A., Copeland, N.G. Development (1998) [Pubmed]
  4. Transcription factors TFE3 and TFEB are critical for CD40 ligand expression and thymus-dependent humoral immunity. Huan, C., Kelly, M.L., Steele, R., Shapira, I., Gottesman, S.R., Roman, C.A. Nat. Immunol. (2006) [Pubmed]
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