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EZH1  -  enhancer of zeste 1 polycomb repressive...

Homo sapiens

Synonyms: ENX-2, Enhancer of zeste homolog 1, Histone-lysine N-methyltransferase EZH1, KIAA0388, KMT6B
 
 
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Psychiatry related information on EZH1

  • The strong sequence conservation suggest potential roles for EZH1 in human development as a transcriptional regulator and as a component of protein complexes that stably maintain heterochromatin [1].
 

High impact information on EZH1

  • A large Cysrich region with a novel spatial pattern of cysteine residues was also conserved in both EZH1 and E(z) [1].
  • EZH1 is expressed as two major transcripts in all adult and fetal human tissues surveyed; comparison of cloned cDNAs suggests that alternative splicing may account for at least part of the transcript size difference [1].
  • Here we report the full-length protein coding sequence of human EZH1 (Enhancer of zeste homolog 1) and compare the respective protein sequences in both species [1].
  • Six consistent ITSs were identified on five of the zebra chromosomes (EZH1p, 1q, 2q, 5q, 6q and 11q) [2].

References

  1. Characterization of EZH1, a human homolog of Drosophila Enhancer of zeste near BRCA1. Abel, K.J., Brody, L.C., Valdes, J.M., Erdos, M.R., McKinley, D.R., Castilla, L.H., Merajver, S.D., Couch, F.J., Friedman, L.S., Ostermeyer, E.A., Lynch, E.D., King, M.C., Welcsh, P.L., Osborne-Lawrence, S., Spillman, M., Bowcock, A.M., Collins, F.S., Weber, B.L. Genomics (1996) [Pubmed]
  2. Interstitial telomeric sites and NORs in Hartmann's zebra (Equus zebra hartmannae) chromosomes. Santani, A., Raudsepp, T., Chowdhary, B.P. Chromosome Res. (2002) [Pubmed]
 
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