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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
MeSH Review

Human Development

 
 
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Disease relevance of Human Development

 

Psychiatry related information on Human Development

 

High impact information on Human Development

 

Chemical compound and disease context of Human Development

  • Thus, the parallel biochemical and molecular genetic analyses of human galactose metabolism are shedding light on this under-appreciated metabolic pathway that is critical for cellular energy production, modification of cellular macromolecules and normal human development [13].
  • Thus, there is a period in pre- and postnatal human development, lasting for several years, during which immature CNS neurons are prone to commit suicide if exposed to intoxicating concentrations of drugs with NMDA antagonist or GABAmimetic properties [14].
  • The early induced genes identified may play a regulatory role in RA-mediated growth suppression and terminal differentiation and may have physiologic or pharmacologic importance during normal human development and retinoid-based cancer therapy or prevention [15].
  • Sulfation of thyroid hormone and dopamine during human development: ontogeny of phenol sulfotransferases and arylsulfatase in liver, lung, and brain [16].
  • Plasma and urine free carnitine concentration during human development was evaluated [17].
 

Biological context of Human Development

 

Anatomical context of Human Development

 

Gene context of Human Development

  • These data show that GLI3 mutations in humans mimic functional effects of the Drosophila ci gene and correlate with the distinct effects of these mutations on human development [28].
  • DVL-1 and DVL-3 are members of a human dsh-like gene family, which is probably involved in human development [29].
  • To study the role of EGF, TGF-alpha and EGFR in early human development, two methods applicable for analysis of expression at the single embryo level have been employed [30].
  • Comparison with previous enzymology studies suggest the changing pattern of 11 beta-HSD2 mRNA is likely to be translated into enzyme activity and have significant parallels in human development [31].
  • We examined the expression of mucin genes, MUC3, 4, 5AC, 5B, 6, 7, and 8 in human fetal tissues to establish the localization and age of onset of expression of each mucin gene during human development [32].
 

Analytical, diagnostic and therapeutic context of Human Development

References

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  15. Developmentally-related candidate retinoic acid target genes regulated early during neuronal differentiation of human embryonal carcinoma. Freemantle, S.J., Kerley, J.S., Olsen, S.L., Gross, R.H., Spinella, M.J. Oncogene (2002) [Pubmed]
  16. Sulfation of thyroid hormone and dopamine during human development: ontogeny of phenol sulfotransferases and arylsulfatase in liver, lung, and brain. Richard, K., Hume, R., Kaptein, E., Stanley, E.L., Visser, T.J., Coughtrie, M.W. J. Clin. Endocrinol. Metab. (2001) [Pubmed]
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  18. Epidermal growth factor signaling via Ras controls the Smad transcriptional co-repressor TGIF. Lo, R.S., Wotton, D., Massagué, J. EMBO J. (2001) [Pubmed]
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