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Gene Review:

JMJD1C - jumonji domain containing 1C

Homo sapiens

Synonyms: DKFZp761F0118, FLJ14374, JHDM2C, Jumonji domain-containing protein 1C, KIAA1380, ...

Katoh, M. et al., Castermans, D. et al.

Katoh, Katoh,

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Psychiatry related information on JMJD1C

Microsatellite marker D10S1225, associated with Alzheimer's disease, non-syndromic congenital retinal non-attachment (NCRNA) and non-syndromic autosomal recessive persistent hyperplastic primary vitreous (arPHPV), was located within the TRIP8-EGR2 locus [1].

High impact information on JMJD1C

These observations suggest that TRIP8 and REEP3 are both positional candidate genes for autism [2].
The distal breakpoint disrupts the TRIP8 gene, which codes for a protein predicted to be a transcriptional regulator associated with nuclear thyroid hormone receptors [2].
Here, we determined the complete coding sequence of TRIP8 gene by using bio-informatics [1].
Nucleotide sequence of full-length TRIP8 cDNA was determined in silico by assembling nucleotide sequences of FLJ14374 and DKFZp761F0118 cDNAs [1].
Human TRIP8 gene, consisting of 26 exons, was about 300 kb in size [1].

Biological context of JMJD1C

Because JMJC domain proteins are implicated in chromatin remodeling, TRIP8 was predicted to be a transcriptional regulator associated with nuclear hormone receptors [1].
Identification and characterization of the TRIP8 and REEP3 genes on chromosome 10q21.3 as novel candidate genes for autism [2].

References

Identification and characterization of TRIP8 gene in silico. Katoh, M., Katoh, M. Int. J. Mol. Med. (2003) [Pubmed]
Identification and characterization of the TRIP8 and REEP3 genes on chromosome 10q21.3 as novel candidate genes for autism. Castermans, D., Vermeesch, J.R., Fryns, J.P., Steyaert, J.G., Van de Ven, W.J., Creemers, J.W., Devriendt, K. Eur. J. Hum. Genet. (2007) [Pubmed]

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