Gene Review:
EGR2 - early growth response 2
Homo sapiens
Synonyms:
AT591, CMT1D, CMT4E, E3 SUMO-protein ligase EGR2, EGR-2, ...
- Novel missense mutation in the early growth response 2 gene associated with Dejerine-Sottas syndrome phenotype. Timmerman, V., De Jonghe, P., Ceuterick, C., De Vriendt, E., Löfgren, A., Nelis, E., Warner, L.E., Lupski, J.R., Martin, J.J., Van Broeckhoven, C. Neurology (1999)
- Novel EGR2 mutation R359Q is associated with CMT type 1 and progressive scoliosis. Mikesová, E., Hühne, K., Rautenstrauss, B., Mazanec, R., Baránková, L., Vyhnálek, M., Horácek, O., Seeman, P. Neuromuscul. Disord. (2005)
- Characterization of a subfamily of zinc finger genes expressed in human hematopoietic cell lines. Munaro, M., Petroni, D., Di Fazio, M., Comi, P., Ottolenghi, S. Cytotechnology. (1991)
- Expression of the early growth response 1 and 2 zinc finger genes during induction of monocytic differentiation. Kharbanda, S., Nakamura, T., Stone, R., Hass, R., Bernstein, S., Datta, R., Sukhatme, V.P., Kufe, D. J. Clin. Invest. (1991)
- Two missense mutations of EGR2 R359W and GJB1 V136A in a Charcot-Marie-Tooth disease family. Chung, K.W., Sunwoo, I.N., Kim, S.M., Park, K.D., Kim, W.K., Kim, T.S., Koo, H., Cho, M., Lee, J., Choi, B.O. Neurogenetics (2005)
- Identification and characterization of TRIP8 gene in silico. Katoh, M., Katoh, M. Int. J. Mol. Med. (2003)
- Mutations in the early growth response 2 (EGR2) gene are associated with hereditary myelinopathies. Warner, L.E., Mancias, P., Butler, I.J., McDonald, C.M., Keppen, L., Koob, K.G., Lupski, J.R. Nat. Genet. (1998)
- Molecular cloning, sequencing, and mapping of EGR2, a human early growth response gene encoding a protein with "zinc-binding finger" structure. Joseph, L.J., Le Beau, M.M., Jamieson, G.A., Acharya, S., Shows, T.B., Rowley, J.D., Sukhatme, V.P. Proc. Natl. Acad. Sci. U.S.A. (1988)
- EGR2 induces apoptosis in various cancer cell lines by direct transactivation of BNIP3L and BAK. Unoki, M., Nakamura, Y. Oncogene (2003)
- Growth-suppressive effects of BPOZ and EGR2, two genes involved in the PTEN signaling pathway. Unoki, M., Nakamura, Y. Oncogene (2001)
- Connexin 32 promoter P2 mutations: a mechanism of peripheral nerve dysfunction. Houlden, H., Girard, M., Cockerell, C., Ingram, D., Wood, N.W., Goossens, M., Walker, R.W., Reilly, M.M. Ann. Neurol. (2004)
- Different consequences of EGR2 mutants on the transactivation of human Cx32 promoter. Musso, M., Balestra, P., Taroni, F., Bellone, E., Mandich, P. Neurobiol. Dis. (2003)
- EGR2 mutation R359W causes a spectrum of Dejerine-Sottas neuropathy. Boerkoel, C.F., Takashima, H., Bacino, C.A., Daentl, D., Lupski, J.R. Neurogenetics (2001)
- Transcriptional activation of human choline acetyltransferase by AP2- and NGF-induced factors. Quirin-Stricker, C., Mauvais, C., Schmitt, M. Brain Res. Mol. Brain Res. (1997)
- Regulation of myelin-specific gene expression. Relevance to CMT1. Kamholz, J., Awatramani, R., Menichella, D., Jiang, H., Xu, W., Shy, M. Ann. N. Y. Acad. Sci. (1999)
- Molecular cloning of a novel human cDNA encoding a zinc finger protein that binds to the interleukin-3 promoter. Koyano-Nakagawa, N., Nishida, J., Baldwin, D., Arai, K., Yokota, T. Mol. Cell. Biol. (1994)
- Modulation of platelet-derived growth factor B mRNA abundance in macrophages by colchicine and dibutyryl-cAMP. Wangoo, A., Haynes, A.R., Sutcliffe, S.P., Sorooshian, M., Shaw, R.J. Mol. Pharmacol. (1992)
- Role for Ca2+ in expression of cell cycle regulated genes in PAF-stimulated cells. Mazer, B.D., Domenico, J., Szepesi, A., Lucas, J.J., Gelfand, E.W. Journal of lipid mediators and cell signalling. (1994)
- A common pattern of persistent gene activation in human neocortical epileptic foci. Rakhade, S.N., Yao, B., Ahmed, S., Asano, E., Beaumont, T.L., Shah, A.K., Draghici, S., Krauss, R., Chugani, H.T., Sood, S., Loeb, J.A. Ann. Neurol. (2005)
- The D355V mutation decreases EGR2 binding to an element within the Cx32 promoter. Musso, M., Balestra, P., Bellone, E., Cassandrini, D., Di Maria, E., Doria, L.L., Grandis, M., Mancardi, G.L., Schenone, A., Levi, G., Ajmar, F., Mandich, P. Neurobiol. Dis. (2001)
- In vivo detection of Egr2 binding to target genes during peripheral nerve myelination. Jang, S.W., LeBlanc, S.E., Roopra, A., Wrabetz, L., Svaren, J. J. Neurochem. (2006)
- Direct regulation of myelin protein zero expression by the Egr2 transactivator. LeBlanc, S.E., Jang, S.W., Ward, R.M., Wrabetz, L., Svaren, J. J. Biol. Chem. (2006)
- Human Connexin 32, a gap junction protein altered in the X-linked form of Charcot-Marie-Tooth disease, is directly regulated by the transcription factor SOX10. Bondurand, N., Girard, M., Pingault, V., Lemort, N., Dubourg, O., Goossens, M. Hum. Mol. Genet. (2001)
- Schwann cells and the pathogenesis of inherited motor and sensory neuropathies (Charcot-Marie-Tooth disease). Berger, P., Niemann, A., Suter, U. Glia (2006)
- Mutation frequency for Charcot-Marie-Tooth disease type 1 in the Chinese population is similar to that in the global ethnic patients. Song, S., Zhang, Y., Chen, B., Zhang, Y., Wang, M., Wang, Y., Yan, M., Zou, J., Huang, Y., Zhong, N. Genet. Med. (2006)
- Search for mutations in the EGR2 corepressor proteins, NAB1 and NAB2, in human peripheral neuropathies. Venken, K., Di Maria, E., Bellone, E., Balestra, P., Cassandrini, D., Mandich, P., De Jonghe, P., Timmerman, V., Svaren, J. Neurogenetics (2002)
- Activity and injury-dependent expression of inducible transcription factors, growth factors and apoptosis-related genes within the central nervous system. Hughes, P.E., Alexi, T., Walton, M., Williams, C.E., Dragunow, M., Clark, R.G., Gluckman, P.D. Prog. Neurobiol. (1999)
- Expression of early growth response genes in human prostate cancer. Eid, M.A., Kumar, M.V., Iczkowski, K.A., Bostwick, D.G., Tindall, D.J. Cancer Res. (1998)