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PRPS1L1  -  phosphoribosyl pyrophosphate synthetase 1...

Homo sapiens

Synonyms: PRPS1, PRPS1-like 1, PRPS3, PRPSL, PRS-III, ...
 
 
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High impact information on PRPS1L1

  • A cDNA clone of PRPS3 was sequenced and found to encode a predicted product of 317 amino acids which was highly homologous to those of PRPS1 and PRPS2 (94.3% and 91.2% identities, respectively) [1].
  • The 20- and 4.3-kb DNA segments did not cosegregate with the other three segments, and spot blot hybridization analysis using flow-sorted human chromosomes indicated that these are the PRPS1-related genes (PRPS1L1 and PRPS1L2) and could be assigned to chromosomes 7 and 9, respectively [2].
 

Biological context of PRPS1L1

  • Two highly homologous subunits for phosphoribosylpyrophosphate synthetase are encoded by human X-linked genes, PRPS1 and PRPS2 (Taira, M., Kudoh, J., Minoshima, S., Iizasa, T., Shimada, H., Shimizu, Y., Tatibana, M., and Shimizu, N. (1989b) Somat. Cell Mol. Genet. 15, 29-37) [1].

References

  1. A human testis-specific mRNA for phosphoribosylpyrophosphate synthetase that initiates from a non-AUG codon. Taira, M., Iizasa, T., Shimada, H., Kudoh, J., Shimizu, N., Tatibana, M. J. Biol. Chem. (1990) [Pubmed]
  2. Localization of human phosphoribosylpyrophosphate synthetase subunit I and II genes (PRPS1 and PRPS2) to different regions of the X chromosome and assignment of two PRPS1-related genes to autosomes. Taira, M., Kudoh, J., Minoshima, S., Iizasa, T., Shimada, H., Shimizu, Y., Tatibana, M., Shimizu, N. Somat. Cell Mol. Genet. (1989) [Pubmed]
 
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