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Gene Review

Usp5  -  ubiquitin specific peptidase 5...

Mus musculus

Synonyms: AA407472, Deubiquitinating enzyme 5, ISOT, ISOT-1, Isopeptidase T, ...
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High impact information on Usp5

  • Although cyclic tri-Ub resists hydrolysis by the PA700 or isopeptidase T deubiquitinating enzymes, it can be disassembled to Ub monomers by isopeptidase(s) in a red blood cell extract [1].
  • Intron 15 in -3 is absent in ISOT-1, there is an alternate splice site at the same location [2].
  • The synthesis of three new potential tumour-imaging radiopharmaceuticals in which a cis-platin derivative is attached to benzyl iminodiacetic acid, a ligand capable of forming a stable complex with 99mTc, has previously been reported by us [Awaluddin et al. Appl. Radiat. Isot. 38, 671-674 (1987)] [3].


  1. Cyclization of polyubiquitin by the E2-25K ubiquitin conjugating enzyme. Yao, T., Cohen, R.E. J. Biol. Chem. (2000) [Pubmed]
  2. The genomic organization of Isopeptidase T-3 (ISOT-3), a new member of the ubiquitin specific protease family (UBP). Timms, K.M., Ansari-Lari, M.A., Morris, W., Brown, S.N., Gibbs, R.A. Gene (1998) [Pubmed]
  3. Biological evaluation of 99mTc labelled cis-platinum containing benzyliminodiacetic acids as potential tumour imaging agents. Jacobs, J.J., Maddalena, D.J., Wilson, J.G., Awaluddin, A., King-Christopher, J., Bourne, D.W. International journal of radiation applications and instrumentation. Part B, Nuclear medicine and biology. (1990) [Pubmed]
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