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Chemical Compound Review

CCRIS 5161     azane; platinum(+2) cation; dichloride

Synonyms: HSDB 3940, AR-1I4195, LS-117696, AKOS015853703, NSC 131558, ...
 
 
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Disease relevance of Platidiam

 

Psychiatry related information on Platidiam

 

High impact information on Platidiam

 

Chemical compound and disease context of Platidiam

 

Biological context of Platidiam

 

Anatomical context of Platidiam

 

Associations of Platidiam with other chemical compounds

 

Gene context of Platidiam

 

Analytical, diagnostic and therapeutic context of Platidiam

  • Hence, by preventing EGFR-mediated survival signaling, the internalization route we uncovered enhances the cytotoxic effect of drugs like cis-platinum, which may underlie interactions between chemotherapy and EGFR-targeting drugs [37].
  • A monoclonal antibody raised against trans-DDP-DNA was competitively inhibited in an ELISA by 40 nM trans-DDP bound to DNA, (D/N)b = 0.022 [38].
  • The cells were treated with cis-dichlorodiammineplatinum and solubilized in NaDodSO4-containing buffer, and the DNA was pelleted by high-speed centrifugation [39].
  • The interaction of cis-diamminedichloroplatinum(II) (c-DDP) with daily fractionated radiotherapy was studied in the SCCVII tumor, the duodenum, and the lungs of C3H/Km mice [40].
  • After this period, as happened also with nodules treated with 5-FUra alone, vigorous regrowth occurred after treatment with cis-DDP plus 5-FUra, and all the nodules regained the size of the controls sooner or later [41].

References

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  20. Binding kinetics of tetrachloro-1,2-diaminocyclohexaneplatinum (IV) (tetraplatin) and cis-diamminedichloroplatinum (II) at 37 degrees C with human plasma proteins and with bovine serum albumin. Does aquation precede protein binding? LeRoy, A.F., Thompson, W.C. J. Natl. Cancer Inst. (1989) [Pubmed]
  21. Phospholipase C-mediated hydrolysis of phosphatidylcholine is activated by cis-diamminedichloroplatinum(II). Nishio, K., Sugimoto, Y., Fujiwara, Y., Ohmori, T., Morikage, T., Takeda, Y., Ohata, M., Saijo, N. J. Clin. Invest. (1992) [Pubmed]
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  25. Identification of semaphorin E as a non-MDR drug resistance gene of human cancers. Yamada, T., Endo, R., Gotoh, M., Hirohashi, S. Proc. Natl. Acad. Sci. U.S.A. (1997) [Pubmed]
  26. Platinum-DNA adducts in leukocyte DNA correlate with disease response in ovarian cancer patients receiving platinum-based chemotherapy. Reed, E., Ozols, R.F., Tarone, R., Yuspa, S.H., Poirier, M.C. Proc. Natl. Acad. Sci. U.S.A. (1987) [Pubmed]
  27. Isolation of cDNAs encoding a human protein that binds selectively to DNA modified by the anticancer drug cis-diamminedichloroplatinum(II). Toney, J.H., Donahue, B.A., Kellett, P.J., Bruhn, S.L., Essigmann, J.M., Lippard, S.J. Proc. Natl. Acad. Sci. U.S.A. (1989) [Pubmed]
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  29. Cisplatin-DNA adducts are molecular decoys for the ribosomal RNA transcription factor hUBF (human upstream binding factor). Treiber, D.K., Zhai, X., Jantzen, H.M., Essigmann, J.M. Proc. Natl. Acad. Sci. U.S.A. (1994) [Pubmed]
  30. Human MutSalpha recognizes damaged DNA base pairs containing O6-methylguanine, O4-methylthymine, or the cisplatin-d(GpG) adduct. Duckett, D.R., Drummond, J.T., Murchie, A.I., Reardon, J.T., Sancar, A., Lilley, D.M., Modrich, P. Proc. Natl. Acad. Sci. U.S.A. (1996) [Pubmed]
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  32. SAPK2/p38-dependent F-actin reorganization regulates early membrane blebbing during stress-induced apoptosis. Huot, J., Houle, F., Rousseau, S., Deschesnes, R.G., Shah, G.M., Landry, J. J. Cell Biol. (1998) [Pubmed]
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  38. Monoclonal antibodies to DNA modified with cis- or trans-diamminedichloroplatinum(II). Sundquist, W.I., Lippard, S.J., Stollar, B.D. Proc. Natl. Acad. Sci. U.S.A. (1987) [Pubmed]
  39. Association of cytokeratin p39 with DNA in intact Novikoff hepatoma cells. Ward, W.S., Schmidt, W.N., Schmidt, C.A., Hnilica, L.S. Proc. Natl. Acad. Sci. U.S.A. (1984) [Pubmed]
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  41. Effects of combined treatments of cis-diamminedichloroplatinum(II), 5-fluorouracil, and X-rays on growth of human cancer nodules maintained in continuous organotypic culture. Beaupain, R., Dionet, C. Cancer Res. (1985) [Pubmed]
 
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