Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Editor

Personal info

View

About

Terms

Javascript disabled

Please enable Javascript support in your browser to use this application.

Instructions on how to enable JavaScript on different browsers can be found here: http://www.google.com/support/bin/answer.py?answer=23852.

[edit this page]

Gene Review:

FEB2 - febrile convulsions 2

Homo sapiens

Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of FEB2

Linkage analysis has excluded both the beta 1 subunit gene (SCN1B) of a voltage-gated sodium (Na+) channel responsible for GEFS+ and the two loci, FEB1 and FEB2, previously implicated in febrile seizures [1].

High impact information on FEB2

Two putative loci have been mapped (FEB1 and FEB2), but specific genes have not yet been identified [2].
Haplotype analysis using both affected and unaffected family members indicates that this febrile convulsion gene, which we call FEB2 , can be localized to an 11.7 cM, 1-2 Mb section of chromosome 19p13.3, between loci D19S591 and D19S395 [3].
More precise mapping indicates that the involvement of FLJ10390 in atherogenic lipoprotein phenotype, familial febrile convulsions 2, and psoriasis susceptibility cannot be ruled out [4].

Biological context of FEB2

METHODS: Members of the two families were genotyped with microsatellite markers linked to the previously identified febrile convulsion loci, FEB1, FEB2, and GEFS+, and we performed two-point linkage analyses by assuming an autosomal dominant mode of inheritance [5].

Other interactions of FEB2

Two putative FS loci, FEB1 (chromosome 8q13-q21) and FEB2 (chromosome 19p13.3) have been mapped [6].

References

A second locus for familial generalized epilepsy with febrile seizures plus maps to chromosome 2q21-q33. Baulac, S., Gourfinkel-An, I., Picard, F., Rosenberg-Bourgin, M., Prud'homme, J.F., Baulac, M., Brice, A., LeGuern, E. Am. J. Hum. Genet. (1999) [Pubmed]
Febrile seizures and generalized epilepsy associated with a mutation in the Na+-channel beta1 subunit gene SCN1B. Wallace, R.H., Wang, D.W., Singh, R., Scheffer, I.E., George, A.L., Phillips, H.A., Saar, K., Reis, A., Johnson, E.W., Sutherland, G.R., Berkovic, S.F., Mulley, J.C. Nat. Genet. (1998) [Pubmed]
Evidence for a novel gene for familial febrile convulsions, FEB2, linked to chromosome 19p in an extended family from the Midwest. Johnson, E.W., Dubovsky, J., Rich, S.S., O'Donovan, C.A., Orr, H.T., Anderson, V.E., Gil-Nagel, A., Ahmann, P., Dokken, C.G., Schneider, D.T., Weber, J.L. Hum. Mol. Genet. (1998) [Pubmed]
Characterization and in silico mapping of a novel murine zinc finger transcription factor. Wride, M.A., Mansergh, F.C., Somani, J.M., Winkfein, R.J., Rancourt, D.E. Gene (2002) [Pubmed]
Evidence favoring genetic heterogeneity for febrile convulsions. Racacho, L.J., McLachlan, R.S., Ebers, G.C., Maher, J., Bulman, D.E. Epilepsia (2000) [Pubmed]
Molecular genetics of febrile seizures. Iwasaki, N., Nakayama, J., Hamano, K., Matsui, A., Arinami, T. Epilepsia (2002) [Pubmed]

Contributions to this collaborative article are from individual authors of WikiGenes or mined by the WikiGenes Data Mining Engine from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.About WikiGenes Open Access Licence Privacy Policy Terms of Use apsburg

The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.