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Gene Review

Tomm22  -  translocase of outer mitochondrial...

Mus musculus

Synonyms: 2310047D01, Mitochondrial import receptor subunit TOM22 homolog, Tom22, Translocase of outer membrane 22 kDa subunit homolog
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High impact information on Tomm22

  • Upon further entry of the preprotein into the translocation pore, the presequence loses its contact with Tom20/Tom22, but remains in firm association with Tom40 [1].
  • It is then transported into the sperm mitochondria by Tom22 and Tom40, where it destroys the sperm mtDNA, establishing the maternal inheritance of mtDNA [2].

Other interactions of Tomm22

  • Preproteins bound to the surface-exposed cis site can be cross-linked via their N-terminal presequence to Tom20 and Tom22, demonstrating their direct association with this part of the preprotein [1].


  1. Mitochondrial protein import. Tom40 plays a major role in targeting and translocation of preproteins by forming a specific binding site for the presequence. Rapaport, D., Neupert, W., Lill, R. J. Biol. Chem. (1997) [Pubmed]
  2. The sperm mitochondria-specific translocator has a key role in maternal mitochondrial inheritance. Hayashida, K., Omagari, K., Masuda, J., Hazama, H., Kadokawa, Y., Ohba, K., Kohno, S. Cell Biol. Int. (2005) [Pubmed]
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