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Tomm22  -  translocase of outer mitochondrial...

Rattus norvegicus

Synonyms: Mitochondrial import receptor subunit TOM22 homolog, TOM22, Tom22, Translocase of outer membrane 22 kDa subunit homolog, rTOM22
 
 
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High impact information on Tomm22

  • Rat Tom22 (rTOM22) is a 142-residue protein, embedded in the outer membrane through the internal transmembrane domain (TMD) with 82 N-terminal residues in the cytosol and 41 C-terminal residues in the intermembrane space [1].
  • Immunoprecipitation demonstrated that OM38 is associated with the major import receptors rTOM20 and rTOM22, and several other unidentified components with molecular masses of 5-10 kDa in digitonin-solubilized membrane: OM10, OM7.5, and OM5 [2].
  • Blue native gel electrophoresis and immunoprecipitation of digitoninsolubilized mitochondrial outer membranes revealed that OM70 was loosely associated with the approximately 400 kDa translocase complex of the mitochondrial outer membrane, which contains rTOM22 and rTOM40 [3].
 

Associations of Tomm22 with chemical compounds

  • Blue native polyacrylamide gel electrophoresis revealed that OM38 is a component of a approximately 400-kDa complex, firmly associating with rTOM22 and loosely associating with rTOM20 [2].

References

  1. Targeting and assembly of rat mitochondrial translocase of outer membrane 22 (TOM22) into the TOM complex. Nakamura, Y., Suzuki, H., Sakaguchi, M., Mihara, K. J. Biol. Chem. (2004) [Pubmed]
  2. Characterization of rat TOM40, a central component of the preprotein translocase of the mitochondrial outer membrane. Suzuki, H., Okazawa, Y., Komiya, T., Saeki, K., Mekada, E., Kitada, S., Ito, A., Mihara, K. J. Biol. Chem. (2000) [Pubmed]
  3. Characterization of rat TOM70 as a receptor of the preprotein translocase of the mitochondrial outer membrane. Suzuki, H., Maeda, M., Mihara, K. J. Cell. Sci. (2002) [Pubmed]
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