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Tomm40  -  translocase of outer mitochondrial...

Mus musculus

Synonyms: AW539759, MOM35, Mitochondrial import receptor subunit TOM40 homolog, Mitochondrial outer membrane protein of 35 kDa, Mom35, ...
 
 
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High impact information on Tomm40

  • We propose that Tom40 forms a major part of the trans presequence binding site [1].
  • It is then transported into the sperm mitochondria by Tom22 and Tom40, where it destroys the sperm mtDNA, establishing the maternal inheritance of mtDNA [2].

References

  1. Mitochondrial protein import. Tom40 plays a major role in targeting and translocation of preproteins by forming a specific binding site for the presequence. Rapaport, D., Neupert, W., Lill, R. J. Biol. Chem. (1997) [Pubmed]
  2. The sperm mitochondria-specific translocator has a key role in maternal mitochondrial inheritance. Hayashida, K., Omagari, K., Masuda, J., Hazama, H., Kadokawa, Y., Ohba, K., Kohno, S. Cell Biol. Int. (2005) [Pubmed]
 
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