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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

Smyd2  -  SET and MYND domain containing 2

Mus musculus

Synonyms: 1110020E07Rik, 4930402C15, Histone methyltransferase SMYD2, KMT3C, N-lysine methyltransferase SMYD2, ...
 
 
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High impact information on Smyd2

  • Finally, we report that exogenous expression of Smyd2 suppresses cell proliferation [1].
  • Identification and characterization of Smyd2: a split SET/MYND domain-containing histone H3 lysine 36-specific methyltransferase that interacts with the Sin3 histone deacetylase complex [1].
  • Smyd2 associates specifically with the Sin3A histone deacetylase complex, which was recently linked to H3K36 methylation within the coding regions of active genes in yeast [1].
  • Although accumulating evidence suggests that methylation of histone 3, lysine 36 (H3K36) is associated with actively transcribed genes, we show that the SET domain of Smyd2 mediates H3K36 dimethylation and that Smyd2 represses transcription from an SV40-luciferase reporter [1].
 

Analytical, diagnostic and therapeutic context of Smyd2

References

  1. Identification and characterization of Smyd2: a split SET/MYND domain-containing histone H3 lysine 36-specific methyltransferase that interacts with the Sin3 histone deacetylase complex. Brown, M.A., Sims, R.J., Gottlieb, P.D., Tucker, P.W. Mol. Cancer (2006) [Pubmed]
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