Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Gene Review:

Nup214 - nucleoporin 214

Mus musculus

Synonyms: 214 kDa nucleoporin, BC039282, CAN, D2H9S46E, Kiaa0023, ...

van Deursen, J. et al., Besirli, C.G. et al.

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Disease relevance of Nup214

One of its components, CAN/Nup214, is an FXFG repeat-containing protein known to be involved in myeloid leukemia in humans [1].

High impact information on Nup214

As potential mediators, we identified additional nuclear MLK/JNK substrates, including Nup214 subunit of the nuclear pore complex [2].
G2 arrest and impaired nucleocytoplasmic transport in mouse embryos lacking the proto-oncogene CAN/Nup214 [1].

References

G2 arrest and impaired nucleocytoplasmic transport in mouse embryos lacking the proto-oncogene CAN/Nup214. van Deursen, J., Boer, J., Kasper, L., Grosveld, G. EMBO J. (1996) [Pubmed]
The limited role of NH2-terminal c-Jun phosphorylation in neuronal apoptosis: identification of the nuclear pore complex as a potential target of the JNK pathway. Besirli, C.G., Wagner, E.F., Johnson, E.M. J. Cell Biol. (2005) [Pubmed]

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