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Gene Review:

Mapkap1 - mitogen-activated protein kinase...

Mus musculus

Synonyms: AI591529, D230039K05Rik, Mip1, Mitogen-activated protein kinase 2-associated protein 1, SAPK-interacting protein 1, ...

Larsen, J.K. et al., Engel, K. et al., Stokoe, D. et al.

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High impact information on Mapkap1

This MAP kinase activated protein kinase, termed MAPKAP kinase-2, was distinguished from S6 kinase-II (MAPKAP kinase-1) by its response to inhibitors, lack of phosphorylation of S6 peptides and amino acid sequence [1].
A recently described downstream target of mitogen-activated protein kinases (MAPKs) is the MAPK-activated protein (MAPKAP) kinase 2 which has been shown to be responsible for small heat shock protein phosphorylation [2].
The canine HSP27 amino acid sequence includes three serine residues corresponding to sites in human HSP27 known to be phosphorylated by mitogen-activated protein kinase-activated protein (MAPKAP) kinase-2 [3].
Phosphorylation of the 27-kDa heat shock protein via p38 MAP kinase and MAPKAP kinase in smooth muscle [3].

References

MAPKAP kinase-2; a novel protein kinase activated by mitogen-activated protein kinase. Stokoe, D., Campbell, D.G., Nakielny, S., Hidaka, H., Leevers, S.J., Marshall, C., Cohen, P. EMBO J. (1992) [Pubmed]
Constitutive activation of mitogen-activated protein kinase-activated protein kinase 2 by mutation of phosphorylation sites and an A-helix motif. Engel, K., Schultz, H., Martin, F., Kotlyarov, A., Plath, K., Hahn, M., Heinemann, U., Gaestel, M. J. Biol. Chem. (1995) [Pubmed]
Phosphorylation of the 27-kDa heat shock protein via p38 MAP kinase and MAPKAP kinase in smooth muscle. Larsen, J.K., Yamboliev, I.A., Weber, L.A., Gerthoffer, W.T. Am. J. Physiol. (1997) [Pubmed]

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AgaP_AGAP008831	Anopheles gambiae str. PEST
MAPKAP1	Bos taurus
MAPKAP1	Canis lupus familiaris
mapkap1	Danio rerio
Sin1	Drosophila melanogaster
MAPKAP1	Gallus gallus
MAPKAP1	Homo sapiens
MAPKAP1	Macaca mulatta
MAPKAP1	Pan troglodytes
Mapkap1	Rattus norvegicus
mapkap1	Xenopus (Silurana) tropicalis

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