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Gene Review:

PUF60 - poly-U binding splicing factor 60KDa

Homo sapiens

Synonyms: 60 kDa poly(U)-binding-splicing factor, FBP-interacting repressor, FIR, FUSE-binding protein-interacting repressor, Poly(U)-binding-splicing factor PUF60, ...

Matsushita, K. et al., Bouffard, P. et al., Bouffard, P. et al., Fouraux, M.A. et al.

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High impact information on SIAHBP1

Recently, an interaction between FUSE-binding protein-interacting repressor (FIR) and TFIIH/p89/XPB helicase was found to repress c-myc transcription and might be important for suppressing tumor formation [1].
An essential role of alternative splicing of c-myc suppressor FUSE-binding protein-interacting repressor in carcinogenesis [1].
The association of three other proteins, namely calreticulin, Ro52 and RoBPI, with (subsets of) the Ro RNPs is still controversial [2].
RoBPI coimmunoprecipitated with Ro RNPs from HeLa cell extracts and partially colocalized with Ro60 in nuclei of cultured cells [3].
Interaction cloning and characterization of RoBPI, a novel protein binding to human Ro ribonucleoproteins [3].

Biological context of SIAHBP1

The RITA assay was further used to detect (rRo60/rhY RNP)-binding proteins from a HeLa cell cDNA library, allowing specific identification of La and of a novel Ro RNP-binding protein (RoBPI) in more than 70% of positive clones [4].

References

An essential role of alternative splicing of c-myc suppressor FUSE-binding protein-interacting repressor in carcinogenesis. Matsushita, K., Tomonaga, T., Shimada, H., Shioya, A., Higashi, M., Matsubara, H., Harigaya, K., Nomura, F., Libutti, D., Levens, D., Ochiai, T. Cancer Res. (2006) [Pubmed]
Nucleolin associates with a subset of the human Ro ribonucleoprotein complexes. Fouraux, M.A., Bouvet, P., Verkaart, S., van Venrooij, W.J., Pruijn, G.J. J. Mol. Biol. (2002) [Pubmed]
Interaction cloning and characterization of RoBPI, a novel protein binding to human Ro ribonucleoproteins. Bouffard, P., Barbar, E., Brière, F., Boire, G. RNA (2000) [Pubmed]
Identification of ribonucleoprotein (RNP)-specific protein interactions using a yeast RNP interaction trap assay (RITA). Bouffard, P., Brière, F., Wellinger, R.J., Boire, G. BioTechniques (1999) [Pubmed]

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AgaP_AGAP010553	Anopheles gambiae str. PEST
PUF60	Bos taurus
rnp-6	Caenorhabditis elegans
PUF60	Canis lupus familiaris
puf60a	Danio rerio
pUf68	Drosophila melanogaster
PUF60	Gallus gallus
PUF60	Macaca mulatta
Puf60	Mus musculus
PUF60	Pan troglodytes
Puf60	Rattus norvegicus
puf60	Xenopus (Silurana) tropicalis

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