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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

PPM1E  -  protein phosphatase, Mg2+/Mn2+ dependent, 1E

Homo sapiens

Synonyms: CAMKN, Ca(2+)/calmodulin-dependent protein kinase phosphatase N, CaMKN, CaMKP-N, CaMKP-nucleus, ...
 
 
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High impact information on PPM1E

  • We now report two PP2C-like serine/threonine phosphatases (POPX1 and POPX2) that efficiently inactivate PAK [1].
  • Consonant with these effects on PAK, POPX can also inhibit actin stress fiber breakdown and morphological changes driven by active Cdc42(V12) [1].
  • POPX1 was isolated as a binding partner for the PAK interacting guanine nucleotide exchange factor PIX [1].

References

  1. The p21-activated kinase PAK is negatively regulated by POPX1 and POPX2, a pair of serine/threonine phosphatases of the PP2C family. Koh, C.G., Tan, E.J., Manser, E., Lim, L. Curr. Biol. (2002) [Pubmed]
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