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Gene Review

PPM1F  -  protein phosphatase, Mg2+/Mn2+ dependent, 1F

Homo sapiens

Synonyms: CAMKP, Ca(2+)/calmodulin-dependent protein kinase phosphatase, CaM-kinase phosphatase, CaMKPase, FEM-2, ...
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High impact information on PPM1F


Biological context of PPM1F

  • Thus, the Glu cluster appeared to be the binding site for polycations and to play a pivotal role in the polycation stimulation of CaMKPase activity [5].

Anatomical context of PPM1F

  • Four occlusal patterns were tested: FEM 1 - standard occlusal contacts; FEM 2 - removal of mesial marginal and mesial tripoidism contacts; FEM 3 - removal of distal marginal and distal tripoidism contacts; FEM 4 - similar to FEM 3 with added contacts between upper and lower incisors [6].

Associations of PPM1F with chemical compounds

  • One of the prominent features of CaMKPase is stimulation of phosphatase activity by polycations such as poly-L-lysine (poly(Lys)) [5].
  • Poly(Lys) failed to stimulate a CaMKPase mutant in which a Glu cluster corresponding to residues 101-109 in the N-terminal domain was deleted, and the mutant could not interact with poly(Lys) in the presence of Mn(2+) [5].

Other interactions of PPM1F

  • Taken together, our data suggest that hFEM-2 and rCaMKPase are mammalian homologues of FEM-2 and they are evolutionarily conserved CaM kinase phosphatases that may have a role in apoptosis signaling [4].

Analytical, diagnostic and therapeutic context of PPM1F


  1. The Caenorhabditis elegans F-box protein SEL-10 promotes female development and may target FEM-1 and FEM-3 for degradation by the proteasome. Jäger, S., Schwartz, H.T., Horvitz, H.R., Conradt, B. Proc. Natl. Acad. Sci. U.S.A. (2004) [Pubmed]
  2. Regulation of the multifunctional Ca2+/calmodulin-dependent protein kinase II by the PP2C phosphatase PPM1F in fibroblasts. Harvey, B.P., Banga, S.S., Ozer, H.L. J. Biol. Chem. (2004) [Pubmed]
  3. The p21-activated kinase PAK is negatively regulated by POPX1 and POPX2, a pair of serine/threonine phosphatases of the PP2C family. Koh, C.G., Tan, E.J., Manser, E., Lim, L. Curr. Biol. (2002) [Pubmed]
  4. The Caenorhabditis elegans sex-determining protein FEM-2 and its human homologue, hFEM-2, are Ca2+/calmodulin-dependent protein kinase phosphatases that promote apoptosis. Tan, K.M., Chan, S.L., Tan, K.O., Yu, V.C. J. Biol. Chem. (2001) [Pubmed]
  5. Stimulation of Ca(2+)/calmodulin-dependent protein kinase phosphatase by polycations. Ishida, A., Kameshita, I., Kitani, T., Okuno, S., Takeuchi, M., Fujisawa, H. Arch. Biochem. Biophys. (2002) [Pubmed]
  6. Tooth displacement due to occlusal contacts: a three-dimensional finite element study. Gomes de Oliveira, S., Seraidarian, P.I., Landre, J., Oliveira, D.D., Cavalcanti, B.N. Journal of oral rehabilitation (2006) [Pubmed]
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