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Gene Review: 

CPEB3  -  cytoplasmic polyadenylation element...

Homo sapiens

Synonyms: CPE-BP3, CPE-binding protein 3, Cytoplasmic polyadenylation element-binding protein 3, KIAA0940, hCPEB-3
 
 
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Disease relevance of CPEB3

  • The CPEB3 ribozyme is structurally and biochemically related to the human hepatitis delta virus (HDV) ribozymes [1].
 

High impact information on CPEB3

  • In transfected neurons, CPEB3 represses the translation of a reporter RNA in tethered function assays; in response to NMDA receptor activation, translation is stimulated [2].
  • In contrast to CPEB, CPEB3-mediated translation is unlikely to involve cytoplasmic polyadenylation, as it requires neither the cis-acting AAUAAA nor the trans-acting cleavage and polyadenylation specificity factor, both of which are necessary for CPEB-induced polyadenylation [2].
  • Proteins (KIAA0940 and KIAA1673) with similar structures are predicted from the genome database, but nothing is known about their expression and function [3].

References

  1. A genomewide search for ribozymes reveals an HDV-like sequence in the human CPEB3 gene. Salehi-Ashtiani, K., Lupták, A., Litovchick, A., Szostak, J.W. Science (2006) [Pubmed]
  2. CPEB3 and CPEB4 in neurons: analysis of RNA-binding specificity and translational control of AMPA receptor GluR2 mRNA. Huang, Y.S., Kan, M.C., Lin, C.L., Richter, J.D. EMBO J. (2006) [Pubmed]
  3. CPEB2, a novel putative translational regulator in mouse haploid germ cells. Kurihara, Y., Tokuriki, M., Myojin, R., Hori, T., Kuroiwa, A., Matsuda, Y., Sakurai, T., Kimura, M., Hecht, N.B., Uesugi, S. Biol. Reprod. (2003) [Pubmed]
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