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Gene Review

DIS3  -  DIS3 exosome endoribonuclease and 3'-5'...

Homo sapiens

Synonyms: 2810028N01Rik, EXOSC11, Exosome complex exonuclease RRP44, KIAA1008, Protein DIS3 homolog, ...
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High impact information on DIS3

  • Double mutant and inhibitor analyses revealed that Dis3 is required for correct kinetochore formation and function, and that this activity is monitored by the Mad2 checkpoint [1].
  • Previous isolation of the dis3-54 cold-sensitive mutant of fission yeast Schizosaccharomyces pombe suggested that Dis3 is also required for correct chromosome segregation [1].


  1. Ribonuclease Activity of Dis3 Is Required for Mitotic Progression and Provides a Possible Link between Heterochromatin and Kinetochore Function. Murakami, H., Goto, D.B., Toda, T., Chen, E.S., Grewal, S.I., Martienssen, R.A., Yanagida, M. PLoS ONE (2007) [Pubmed]
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