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Gene Review

DIS3  -  exosome catalytic subunit DIS3

Saccharomyces cerevisiae S288c

Synonyms: Chromosome disjunction protein 3, Exosome complex exonuclease DIS3, MTR17, O2197, RRP44, ...
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High impact information on DIS3

  • Nuclear export of scR1 is mediated by the nuclear export signal receptor Xpo1p, is distinct from mRNA transport, and requires, as evidenced by the nucleolar accumulation of scR1 in a dis3/rrp44 exosome component mutant, an intact scR1 3' end [1].
  • The DIS3 gene is essential for viability and complements S.pombe mutant dis3-54 which is defective in mitosis [2].
  • Here, we show that the cyt-4+ gene encodes a 120-kDa protein with significant similarity to the SSD1/SRK1 protein of Saccharomyces cerevisiae and the DIS3 protein of Schizosaccharomyces pombe, which have been implicated in protein phosphatase functions that regulate cell cycle and mitotic chromosome segregation [3].
  • Increased dis3+ gene dosage reverses the Ts+ phenotype of a cdc25 wee1 strain, as does increased type 1 protein phosphatase gene dosage [4].
  • The dis3+ gene is essential for growth; gene disruptant cells do not germinate and fail in cell division [4].

Biological context of DIS3


Associations of DIS3 with chemical compounds


Regulatory relationships of DIS3


Other interactions of DIS3

  • In contrast, the 5' end of 5.8S rRNA was terminated normally in gsp1 and in dis3 [10].


  1. Biogenesis of the signal recognition particle (SRP) involves import of SRP proteins into the nucleolus, assembly with the SRP-RNA, and Xpo1p-mediated export. Grosshans, H., Deinert, K., Hurt, E., Simos, G. J. Cell Biol. (2001) [Pubmed]
  2. Dis3, implicated in mitotic control, binds directly to Ran and enhances the GEF activity of RCC1. Noguchi, E., Hayashi, N., Azuma, Y., Seki, T., Nakamura, M., Nakashima, N., Yanagida, M., He, X., Mueller, U., Sazer, S., Nishimoto, T. EMBO J. (1996) [Pubmed]
  3. A protein required for RNA processing and splicing in Neurospora mitochondria is related to gene products involved in cell cycle protein phosphatase functions. Turcq, B., Dobinson, K.F., Serizawa, N., Lambowitz, A.M. Proc. Natl. Acad. Sci. U.S.A. (1992) [Pubmed]
  4. The fission yeast dis3+ gene encodes a 110-kDa essential protein implicated in mitotic control. Kinoshita, N., Goebl, M., Yanagida, M. Mol. Cell. Biol. (1991) [Pubmed]
  5. Human dis3p, which binds to either GTP- or GDP-Ran, complements Saccharomyces cerevisiae dis3. Shiomi, T., Fukushima, K., Suzuki, N., Nakashima, N., Noguchi, E., Nishimoto, T. J. Biochem. (1998) [Pubmed]
  6. The fission yeast sts5+ gene is required for maintenance of growth polarity and functionally interacts with protein kinase C and an osmosensing MAP-kinase pathway. Toda, T., Niwa, H., Nemoto, T., Dhut, S., Eddison, M., Matsusaka, T., Yanagida, M., Hirata, D. J. Cell. Sci. (1996) [Pubmed]
  7. Isolation of murine and human homologues of the fission-yeast dis3+ gene encoding a mitotic-control protein and its overexpression in cancer cells with progressive phenotype. Lim, J., Kuroki, T., Ozaki, K., Kohsaki, H., Yamori, T., Tsuruo, T., Nakamori, S., Imaoka, S., Endo, M., Nakamura, Y. Cancer Res. (1997) [Pubmed]
  8. Analysis of the DNA sequence of a 34,038 bp region on the left arm of yeast chromosome XV. Rad, M.R., Habbig, B., Jansen, G., Hattenhorst, U., Kroll, M., Hollenberg, C.P. Yeast (1997) [Pubmed]
  9. The SIT4 protein phosphatase functions in late G1 for progression into S phase. Sutton, A., Immanuel, D., Arndt, K.T. Mol. Cell. Biol. (1991) [Pubmed]
  10. The Saccharomyces cerevisiae small GTPase, Gsp1p/Ran, is involved in 3' processing of 7S-to-5.8S rRNA and in degradation of the excised 5'-A0 fragment of 35S pre-rRNA, both of which are carried out by the exosome. Suzuki, N., Noguchi, E., Nakashima, N., Oki, M., Ohba, T., Tartakoff, A., Ohishi, M., Nishimoto, T. Genetics (2001) [Pubmed]
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