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Gene Review

PLA2R1  -  phospholipase A2 receptor 1, 180kDa

Homo sapiens

Synonyms: 180 kDa secretory phospholipase A2 receptor, C-type lectin domain family 13 member C, CLEC13C, M-type receptor, PLA2-R, ...
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High impact information on PLA2R1

  • They also showed an increased affinity for calmodulin, a recently identified high-affinity binding protein for Atxs, whereas affinity for a neuronal M-type PLA2 receptor remained largely unchanged [1].
  • The presence of PLA2 receptor mRNA in human gestational tissues indicates that an alternative non-catalytic pathway may contribute to the regulatory effects of sPLA2 isozymes in these tissues [2].
  • Messenger RNA for the PLA2 receptor was detected in amnion, choriodecidua and placenta by RT-PCR and transcripts of similar size to the 6.5- and 5.4-kb transcripts previously reported in various other human tissues were detected in choriodecidua by Northern blot analysis [2].


  1. The C-terminal region of ammodytoxins is important but not sufficient for neurotoxicity. Prijatelj, P., Krizaj, I., Kralj, B., Gubensek, F., Pungercar, J. Eur. J. Biochem. (2002) [Pubmed]
  2. Distribution of the phospholipase A2 receptor messenger RNA in human gestational tissues. Moses, E.K., Freed, K.A., Brennecke, S.P., Rice, G.E. Placenta (1998) [Pubmed]
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