The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review


Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of Amnion


High impact information on Amnion

  • However, OT is also synthesized in peripheral tissues, e.g., uterus, placenta, amnion, corpus luteum, testis, and heart [6].
  • To understand the role of proteinases in tumor invasion, the effects of inhibitors of metallo-, serine-, and cysteine-proteinases on this process were studied using 125I-iododeoxyuridine-labeled B16/BL6 cells grown on human amnion basement membrane [7].
  • Tumor invasion through the human amniotic membrane: requirement for a proteinase cascade [7].
  • The endodermal portion of the visceral yolk sac did not react, while small amounts were found in the amnion [8].
  • Noradrenaline induced an interferon-like antiviral state in mouse myocardial cells but not human amnion (WISH) cells [9].

Chemical compound and disease context of Amnion


Biological context of Amnion


Anatomical context of Amnion


Associations of Amnion with chemical compounds


Gene context of Amnion

  • In an in vitro amnion invasion assay system, rTIMP inhibited the invasion of B16-F10 murine melanoma cells through the human amniotic membrane at an identical concentration to that reported previously for natural TIMP [30].
  • One striking defect in Hand1-null embryos was the accumulation of hematopoietic cells between the yolk sac and the amnion because of defects in the yolk sac vasculature [31].
  • In Pitx2(-)(/)(-) embryos there was an increase in mesodermal cells in the distal end of the left lateral body wall and an amnion continuous with the lateral body wall thickened in its mesodermal layer [32].
  • In this investigation we sought to identify the specific endothelin (ET) gene that is expressed in amnion and to determine whether endothelin is produced by amnion [18].
  • Northern analysis with use of locus-specific probes demonstrated that amnion expresses two class Ib genes, HLA-E and HLA-G [33].

Analytical, diagnostic and therapeutic context of Amnion


  1. NIH/3T3 cells transfected with human tumor DNA containing activated ras oncogenes express the metastatic phenotype in nude mice. Thorgeirsson, U.P., Turpeenniemi-Hujanen, T., Williams, J.E., Westin, E.H., Heilman, C.A., Talmadge, J.E., Liotta, L.A. Mol. Cell. Biol. (1985) [Pubmed]
  2. Expression and regulation by interferon of a double-stranded-RNA-specific adenosine deaminase from human cells: evidence for two forms of the deaminase. Patterson, J.B., Samuel, C.E. Mol. Cell. Biol. (1995) [Pubmed]
  3. Suppression by cathepsin L inhibitors of the invasion of amnion membranes by murine cancer cells. Yagel, S., Warner, A.H., Nellans, H.N., Lala, P.K., Waghorne, C., Denhardt, D.T. Cancer Res. (1989) [Pubmed]
  4. Mechanism of interferon action: inhibition of vesicular stomatitis virus replication in human amnion U cells by cloned human leukocyte interferon. II. Effect on viral macromolecular synthesis. Masters, P.S., Samuel, C.E. J. Biol. Chem. (1983) [Pubmed]
  5. Reduction of extracellular matrix protein expression in human amnion epithelial cells by glucocorticoids: a potential role in preterm rupture of the fetal membranes. Guller, S., Kong, L., Wozniak, R., Lockwood, C.J. J. Clin. Endocrinol. Metab. (1995) [Pubmed]
  6. The oxytocin receptor system: structure, function, and regulation. Gimpl, G., Fahrenholz, F. Physiol. Rev. (2001) [Pubmed]
  7. Tumor invasion through the human amniotic membrane: requirement for a proteinase cascade. Mignatti, P., Robbins, E., Rifkin, D.B. Cell (1986) [Pubmed]
  8. The localization and synthesis of some collagen types in developing mouse embryos. Adamson, E.D., Ayers, S.E. Cell (1979) [Pubmed]
  9. Common pathways of interferon and hormonal action. Blalock, J.E., Stanton, J.D. Nature (1980) [Pubmed]
  10. Inhibition of proteolytic enzymes in the in vitro amnion model for basement membrane invasion. Persky, B., Ostrowski, L.E., Pagast, P., Ahsan, A., Schultz, R.M. Cancer Res. (1986) [Pubmed]
  11. Selective intrapartum chemoprophylaxis of neonatal group B streptococcal early-onset disease. III. Interruption of mother-to-infant transmission. Boyer, K.M., Gadzala, C.A., Kelly, P.D., Gotoff, S.P. J. Infect. Dis. (1983) [Pubmed]
  12. Transforming growth factor-beta opposes the stimulatory effects of interleukin-1 and tumor necrosis factor on amnion cell prostaglandin E2 production: implication for preterm labor. Bry, K., Hallman, M. Am. J. Obstet. Gynecol. (1992) [Pubmed]
  13. Cytokine and prostaglandin production by amnion cells in response to the addition of different bacteria. Reisenberger, K., Egarter, C., Knöfler, M., Schiebel, I., Gregor, H., Hirschl, A.M., Heinze, G., Husslein, P. Am. J. Obstet. Gynecol. (1998) [Pubmed]
  14. Preterm labor: stimulation of arachidonic acid metabolism in human amnion cells by bacterial products. Bennett, P.R., Rose, M.P., Myatt, L., Elder, M.G. Am. J. Obstet. Gynecol. (1987) [Pubmed]
  15. A program of cell death and extracellular matrix degradation is activated in the amnion before the onset of labor. Lei, H., Furth, E.E., Kalluri, R., Chiou, T., Tilly, K.I., Tilly, J.L., Elkon, K.B., Jeffrey, J.J., Strauss, J.F. J. Clin. Invest. (1996) [Pubmed]
  16. Correlation of cell migration, cell invasion, receptor number, proteinase production, and basic fibroblast growth factor levels in endothelial cells. Tsuboi, R., Sato, Y., Rifkin, D.B. J. Cell Biol. (1990) [Pubmed]
  17. Increased phosphorylation of elongation factor 2 during mitosis in transformed human amnion cells correlates with a decreased rate of protein synthesis. Celis, J.E., Madsen, P., Ryazanov, A.G. Proc. Natl. Acad. Sci. U.S.A. (1990) [Pubmed]
  18. Endothelin-1 gene expression and regulation of endothelin mRNA and protein biosynthesis in avascular human amnion. Potential source of amniotic fluid endothelin. Casey, M.L., Word, R.A., MacDonald, P.C. J. Biol. Chem. (1991) [Pubmed]
  19. Expression and localization of prostaglandin E synthase isoforms in human fetal membranes in term and preterm labor. Meadows, J.W., Eis, A.L., Brockman, D.E., Myatt, L. J. Clin. Endocrinol. Metab. (2003) [Pubmed]
  20. Murine FGFR-1 is required for early postimplantation growth and axial organization. Deng, C.X., Wynshaw-Boris, A., Shen, M.M., Daugherty, C., Ornitz, D.M., Leder, P. Genes Dev. (1994) [Pubmed]
  21. Synthesis of oxytocin in amnion, chorion, and decidua may influence the timing of human parturition. Chibbar, R., Miller, F.D., Mitchell, B.F. J. Clin. Invest. (1993) [Pubmed]
  22. Effect of glycosaminoglycans and enzymes on the integrity of human placental amnion as a barrier to cell invasion. Turley, E., Tretiak, M., Tanguay, K. J. Natl. Cancer Inst. (1987) [Pubmed]
  23. Laminin promotes rabbit neutrophil motility and attachment. Terranova, V.P., DiFlorio, R., Hujanen, E.S., Lyall, R.M., Liotta, L.A., Thorgeirsson, U., Siegal, G.P., Schiffmann, E. J. Clin. Invest. (1986) [Pubmed]
  24. Expression of c-onc genes: c-fos transcripts accumulate to high levels during development of mouse placenta, yolk sac and amnion. Müller, R., Verma, I.M., Adamson, E.D. EMBO J. (1983) [Pubmed]
  25. Effect of cortisol, prolactin and ADH on the amniotic membrane. Manku, M.S., Mtabaji, J.P., Horrobin, D.F. Nature (1975) [Pubmed]
  26. Cachectin/tumor necrosis factor-alpha formation in human decidua. Potential role of cytokines in infection-induced preterm labor. Casey, M.L., Cox, S.M., Beutler, B., Milewich, L., MacDonald, P.C. J. Clin. Invest. (1989) [Pubmed]
  27. Laminin molecular domains which alter metastasis in a murine model. Barsky, S.H., Rao, C.N., Williams, J.E., Liotta, L.A. J. Clin. Invest. (1984) [Pubmed]
  28. Effect of bacterial products on prostaglandin E production by amnion cells. Lamont, R.F., Rose, M., Elder, M.G. Lancet (1985) [Pubmed]
  29. Homing of hemopoietic precursor cells to the embryonic thymus: characterization of an invasive mechanism induced by chemotactic peptides. Savagner, P., Imhof, B.A., Yamada, K.M., Thiery, J.P. J. Cell Biol. (1986) [Pubmed]
  30. Inhibition by human recombinant tissue inhibitor of metalloproteinases of human amnion invasion and lung colonization by murine B16-F10 melanoma cells. Schultz, R.M., Silberman, S., Persky, B., Bajkowski, A.S., Carmichael, D.F. Cancer Res. (1988) [Pubmed]
  31. Extra-embryonic vasculature development is regulated by the transcription factor HAND1. Morikawa, Y., Cserjesi, P. Development (2004) [Pubmed]
  32. Mouse Pitx2 deficiency leads to anomalies of the ventral body wall, heart, extra- and periocular mesoderm and right pulmonary isomerism. Kitamura, K., Miura, H., Miyagawa-Tomita, S., Yanazawa, M., Katoh-Fukui, Y., Suzuki, R., Ohuchi, H., Suehiro, A., Motegi, Y., Nakahara, Y., Kondo, S., Yokoyama, M. Development (1999) [Pubmed]
  33. The human amnion is a site of MHC class Ib expression: evidence for the expression of HLA-E and HLA-G. Houlihan, J.M., Biro, P.A., Harper, H.M., Jenkinson, H.J., Holmes, C.H. J. Immunol. (1995) [Pubmed]
  34. Immunofluorescence shows localisation of prolactin to human amnion. Healy, D.L., Muller, H.K., Burger, H.G. Nature (1977) [Pubmed]
  35. Steroids modulate corticotropin-releasing hormone production in human fetal membranes and placenta. Jones, S.A., Brooks, A.N., Challis, J.R. J. Clin. Endocrinol. Metab. (1989) [Pubmed]
  36. Parathyroid hormone-related protein mRNA in avascular human amnion. Germain, A.M., Attaroglu, H., MacDonald, P.C., Casey, M.L. J. Clin. Endocrinol. Metab. (1992) [Pubmed]
WikiGenes - Universities