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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

DAAM1  -  dishevelled associated activator of...

Homo sapiens

Synonyms: Disheveled-associated activator of morphogenesis 1, KIAA0666
 
 
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High impact information on DAAM1

  • DAAM1 was shown to bind to the SH3 domain of CIP4 in vivo [1].
  • Coimmunoprecipitation experiments demonstrated that DAAM1 bound to RhoA and Cdc42 in a GTP-dependent manner [1].
  • Moreover, DAAM1 was found to interact and collaborate with the non-receptor tyrosine kinase Src in the formation of branched protrusions [1].
  • Ectopically expressed DAAM1 localised in dotted pattern at the dorsal side of transfected cells and the protein was accumulated in the proximity to the microtubule organising centre [1].
  • Moreover, ectopic expression of DAAM1 induced a marked alteration of the cell morphology, seen as rounding up of the cells, the formation of branched protrusions as well as a reduction of stress-fibres in the transfected cells [1].
 

Other interactions of DAAM1

  • DAAM2 was a 1077-amino-acid protein with Formin-homology FH1 and FH2 domains, which showed 68.9% total-amino-acid identity with DAAM1 [2].
  • One of the CIP4-binding proteins, DAAM1, was characterised in more detail [1].

References

  1. The diaphanous-related formin DAAM1 collaborates with the Rho GTPases RhoA and Cdc42, CIP4 and Src in regulating cell morphogenesis and actin dynamics. Aspenström, P., Richnau, N., Johansson, A.S. Exp. Cell Res. (2006) [Pubmed]
  2. Identification and characterization of human DAAM2 gene in silico. Katoh, M., Katoh, M. Int. J. Oncol. (2003) [Pubmed]
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