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Gene Review

TRIP10  -  thyroid hormone receptor interactor 10

Homo sapiens

Synonyms: CIP4, Cdc42-interacting protein 4, HSTP, Protein Felic, STOT, ...
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Disease relevance of TRIP10


Psychiatry related information on TRIP10


High impact information on TRIP10


Chemical compound and disease context of TRIP10

  • These results provide evidence that combined therapy with furosemide and albumin is effective in augmenting serum albumin and STP levels, promoting weight loss, and improving oxygenation and longer-term hemodynamic stability [8].

Biological context of TRIP10


Anatomical context of TRIP10


Associations of TRIP10 with chemical compounds


Physical interactions of TRIP10


Regulatory relationships of TRIP10


Other interactions of TRIP10

  • FNBP1L (547 aa) showed 59.4 and 55.4% total-amino-acid identity with FNBP1 and TRIP10, respectively [15].
  • Marked CIP4 overexpression also was observed in Western blot from human HD brain striatum [1].
  • CIP4, like WASP, is a Cdc42 effector protein involved in cytoskeletal organization [10].
  • Overexpression of mutant forms of CIP4/2 containing an N-terminal deletion or with diminished TC10 binding inhibits insulin-stimulated Glut4 translocation [6].
  • Similar LexA fusions to Trip9 and Trip10 had no transcriptional activity on their own but, when coexpressed with both TR and RXR, conferred T3-dependent activation to a reporter gene controlled by LexA binding sites [16].

Analytical, diagnostic and therapeutic context of TRIP10


  1. Cdc42-interacting protein 4 binds to huntingtin: neuropathologic and biological evidence for a role in Huntington's disease. Holbert, S., Dedeoglu, A., Humbert, S., Saudou, F., Ferrante, R.J., Néri, C. Proc. Natl. Acad. Sci. U.S.A. (2003) [Pubmed]
  2. Splicing variant of Cdc42 interacting protein-4 disrupts beta-catenin-mediated cell-cell adhesion: expression and function in renal cell carcinoma. Tsuji, E., Tsuji, Y., Fujiwara, T., Ogata, S., Tsukamoto, K., Saku, K. Biochem. Biophys. Res. Commun. (2006) [Pubmed]
  3. Molecular cloning and chromosomal localization of human salt-tolerant protein. Tsuji, E., Tsuji, Y. Genetica (2000) [Pubmed]
  4. Deregulation of cell growth by the K1 gene of Kaposi's sarcoma-associated herpesvirus. Lee, H., Veazey, R., Williams, K., Li, M., Guo, J., Neipel, F., Fleckenstein, B., Lackner, A., Desrosiers, R.C., Jung, J.U. Nat. Med. (1998) [Pubmed]
  5. Coordination between the actin cytoskeleton and membrane deformation by a novel membrane tubulation domain of PCH proteins is involved in endocytosis. Tsujita, K., Suetsugu, S., Sasaki, N., Furutani, M., Oikawa, T., Takenawa, T. J. Cell Biol. (2006) [Pubmed]
  6. The TC10-interacting protein CIP4/2 is required for insulin-stimulated Glut4 translocation in 3T3L1 adipocytes. Chang, L., Adams, R.D., Saltiel, A.R. Proc. Natl. Acad. Sci. U.S.A. (2002) [Pubmed]
  7. Felic (CIP4b), a novel binding partner with the Src kinase Lyn and Cdc42, localizes to the phagocytic cup. Dombrosky-Ferlan, P., Grishin, A., Botelho, R.J., Sampson, M., Wang, L., Rudert, W.A., Grinstein, S., Corey, S.J. Blood (2003) [Pubmed]
  8. Fluid balance and colloid osmotic pressure in acute respiratory failure: emerging clinical evidence. Martin, G.S. Critical care (London, England) (2000) [Pubmed]
  9. Rich, a rho GTPase-activating protein domain-containing protein involved in signaling by Cdc42 and Rac1. Richnau, N., Aspenström, P. J. Biol. Chem. (2001) [Pubmed]
  10. Cdc42-interacting protein 4 mediates binding of the Wiskott-Aldrich syndrome protein to microtubules. Tian, L., Nelson, D.L., Stewart, D.M. J. Biol. Chem. (2000) [Pubmed]
  11. Microtubule-dependent formation of podosomal adhesion structures in primary human macrophages. Linder, S., Hüfner, K., Wintergerst, U., Aepfelbacher, M. J. Cell. Sci. (2000) [Pubmed]
  12. A Cdc42 target protein with homology to the non-kinase domain of FER has a potential role in regulating the actin cytoskeleton. Aspenström, P. Curr. Biol. (1997) [Pubmed]
  13. Identification and genetic analysis of human and mouse activated Cdc42 interacting protein-4 isoforms. Wang, L., Rudert, W.A., Grishin, A., Dombrosky-Ferlan, P., Sullivan, K., Deng, X., Whitcomb, D., Corey, S. Biochem. Biophys. Res. Commun. (2002) [Pubmed]
  14. The diaphanous-related formin DAAM1 collaborates with the Rho GTPases RhoA and Cdc42, CIP4 and Src in regulating cell morphogenesis and actin dynamics. Aspenström, P., Richnau, N., Johansson, A.S. Exp. Cell Res. (2006) [Pubmed]
  15. Identification and characterization of human FNBP1L gene in silico. Katoh, M., Katoh, M. Int. J. Mol. Med. (2004) [Pubmed]
  16. Two classes of proteins dependent on either the presence or absence of thyroid hormone for interaction with the thyroid hormone receptor. Lee, J.W., Choi, H.S., Gyuris, J., Brent, R., Moore, D.D. Mol. Endocrinol. (1995) [Pubmed]
  17. Transduction of HOXD3-antisense into human melanoma cells results in decreased invasive and motile activities. Okubo, Y., Hamada, J., Takahashi, Y., Tada, M., Tsutsumida, A., Furuuchi, K., Aoyama, T., Sugihara, T., Moriuchi, T. Clin. Exp. Metastasis (2002) [Pubmed]
  18. Function and expression of a novel rat salt-tolerant protein: evidence of a role in cellular sodium metabolism. Tsuji, E., Tsuji, Y., Sasaguri, M., Arakawa, K. J. Am. Soc. Nephrol. (1998) [Pubmed]
  19. The state of the serotonin transporter protein in the platelets of patients with somatoform [correction of somatiform] disorders. Belous, A.R., Ramamoorthy, S., Blakely, R.D., Factor, M.I., Dupin, A.M., Katasonov, A.B., Lozier, R.H., Beniashvili, A.G., Morozova, M.A., Brusov, O.S. Neurosci. Behav. Physiol. (2001) [Pubmed]
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