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Gene Review:

PDZRN3 - PDZ domain containing ring finger 3

Homo sapiens

Synonyms: E3 ubiquitin-protein ligase PDZRN3, KIAA1095, LNX3, Ligand of Numb protein X 3, PDZ domain-containing RING finger protein 3, ...

Ko, J.A. et al., Santin, A.D. et al., Katoh, M. et al.

Santin, Zhan, Cane', Bellone, Palmieri, Thomas, Burnett, Roman, Cannon, Shaughnessy, Pecorelli, Katoh, Katoh,

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Disease relevance of PDZRN3

Downregulated genes in USPC included SEMACAP3, ras homolog gene family, member I (ARHI), and differentially downregulated in ovarian carcinoma gene 1 [1].

High impact information on PDZRN3

Depletion of PDZRN3 by RNA interference inhibited the formation of myotubes as well as the associated up-regulation of myosin heavy chain in C2C12 cells [2].
Our data suggest that PDZRN3 plays an essential role in the differentiation of myoblasts into myotubes by acting either downstream or independently of myogenin [2].
The PDZRN3 gene was shown to be expressed in various human tissues including the heart, skeletal muscle and liver and its expression in mouse skeletal muscle was developmentally regulated [2].
PDZRN3 (1066 aa) and PDZRN4 (1036 aa) showed 59.9% total-amino-acid identity [3].

Biological context of PDZRN3

Both the differentiation of C2C12 mouse skeletal myoblasts into myotubes and injury-induced muscle regeneration in vivo were found to be accompanied by up-regulation of PDZRN3 [2].

References

Gene expression fingerprint of uterine serous papillary carcinoma: identification of novel molecular markers for uterine serous cancer diagnosis and therapy. Santin, A.D., Zhan, F., Cane', S., Bellone, S., Palmieri, M., Thomas, M., Burnett, A., Roman, J.J., Cannon, M.J., Shaughnessy, J., Pecorelli, S. Br. J. Cancer (2005) [Pubmed]
PDZRN3 (LNX3, SEMCAP3) is required for the differentiation of C2C12 myoblasts into myotubes. Ko, J.A., Kimura, Y., Matsuura, K., Yamamoto, H., Gondo, T., Inui, M. J. Cell. Sci. (2006) [Pubmed]
Identification and characterization of PDZRN3 and PDZRN4 genes in silico. Katoh, M., Katoh, M. Int. J. Mol. Med. (2004) [Pubmed]

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PDZRN3	Bos taurus
pdzrn3b	Danio rerio
PDZRN3	Gallus gallus
PDZRN3	Macaca mulatta
Pdzrn3	Mus musculus
PDZRN3	Pan troglodytes
Pdzrn3	Rattus norvegicus
pdzrn3	Xenopus (Silurana) tropicalis

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