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Gene Review

KDM4B  -  lysine (K)-specific demethylase 4B

Homo sapiens

Synonyms: JHDM3B, JMJD2B, JmjC domain-containing histone demethylation protein 3B, Jumonji domain-containing protein 2B, KIAA0876, ...
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High impact information on JMJD2B

  • JMJD2A and JMJD2B exhibit cell type-specific responses to the HDAC inhibitor trichostatin A [1].
  • JD2H domain with C2HC2HC2- and C5HC2-type Cys (His) clusters was identified as the region conserved among JMJD2A (1064 aa), JMJD2B (1096 aa), and JMJD2C (1056 aa) proteins [2].

Biological context of JMJD2B


  1. Functional characterization of JMJD2A, a histone deacetylase- and retinoblastoma-binding protein. Gray, S.G., Iglesias, A.H., Lizcano, F., Villanueva, R., Camelo, S., Jingu, H., Teh, B.T., Koibuchi, N., Chin, W.W., Kokkotou, E., Dangond, F. J. Biol. Chem. (2005) [Pubmed]
  2. Identification and characterization of JMJD2 family genes in silico. Katoh, M., Katoh, M. Int. J. Oncol. (2004) [Pubmed]
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