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Gene Review

KDM4C  -  lysine (K)-specific demethylase 4C

Homo sapiens

Synonyms: GASC-1 protein, GASC1, Gene amplified in squamous cell carcinoma 1 protein, JHDM3C, JMJD2C, ...
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Disease relevance of JMJD2C


High impact information on JMJD2C


Biological context of JMJD2C


  1. Identification and characterization of JMJD2 family genes in silico. Katoh, M., Katoh, M. Int. J. Oncol. (2004) [Pubmed]
  2. Identification of a novel gene, GASC1, within an amplicon at 9p23-24 frequently detected in esophageal cancer cell lines. Yang, Z.Q., Imoto, I., Fukuda, Y., Pimkhaokham, A., Shimada, Y., Imamura, M., Sugano, S., Nakamura, Y., Inazawa, J. Cancer Res. (2000) [Pubmed]
  3. A novel amplicon at 9p23 - 24 in squamous cell carcinoma of the esophagus that lies proximal to GASC1 and harbors NFIB. Yang, Z.Q., Imoto, I., Pimkhaokham, A., Shimada, Y., Sasaki, K., Oka, M., Inazawa, J. Jpn. J. Cancer Res. (2001) [Pubmed]
  4. Molecular cytogenetic characterization of a metastatic lung sarcomatoid carcinoma: 9p23 neocentromere and 9p23-p24 amplification including JAK2 and JMJD2C. Italiano, A., Attias, R., Aurias, A., Pérot, G., Burel-Vandenbos, F., Otto, J., Venissac, N., Pedeutour, F. Cancer Genet. Cytogenet. (2006) [Pubmed]
  5. The putative oncogene GASC1 demethylates tri- and dimethylated lysine 9 on histone H3. Cloos, P.A., Christensen, J., Agger, K., Maiolica, A., Rappsilber, J., Antal, T., Hansen, K.H., Helin, K. Nature (2006) [Pubmed]
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