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Gene Review

TNIK  -  TRAF2 and NCK interacting kinase

Homo sapiens

Synonyms: KIAA0551, TRAF2 and NCK-interacting protein kinase
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High impact information on TNIK

  • When co-expressed in cultured cells, TNIK colocalized with Rap2, while a mutant TNIK lacking the CNH domain did not [1].
  • However, in contrast to other GCKs, this activation is mediated solely by the GCK homology region of TNIK [2].
  • In addition, in Phoenix-A, NIH-3T3, and Hela cells, overexpression of wild type TNIK, but not the kinase mutant form of TNIK, results in the disruption of F-actin structure and the inhibition of cell spreading [2].
  • The closest experimentally verified gene in the region (TNIK, encoding a serine/threonine kinase) occurs approximately 63 Kb downstream from the repeat [3].

Other interactions of TNIK

  • Rap2 potently enhanced the inhibitory function of TNIK against cell spreading, but this was not observed for the mutant TNIK lacking the CNH domain [1].

Analytical, diagnostic and therapeutic context of TNIK


  1. The Traf2- and Nck-interacting kinase as a putative effector of Rap2 to regulate actin cytoskeleton. Taira, K., Umikawa, M., Takei, K., Myagmar, B.E., Shinzato, M., Machida, N., Uezato, H., Nonaka, S., Kariya, K. J. Biol. Chem. (2004) [Pubmed]
  2. TNIK, a novel member of the germinal center kinase family that activates the c-Jun N-terminal kinase pathway and regulates the cytoskeleton. Fu, C.A., Shen, M., Huang, B.C., Lasaga, J., Payan, D.G., Luo, Y. J. Biol. Chem. (1999) [Pubmed]
  3. A novel trinucleotide repeat expansion at chromosome 3q26.2 identified by a CAG/CTG repeat expansion detection array. Holmes, S.E., Wentzell, J.S., Seixas, A.I., Callahan, C., Silveira, I., Ross, C.A., Margolis, R.L. Hum. Genet. (2006) [Pubmed]
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