Disease relevance of SYNE2

• From these results it is concluded that a) the effects of a reduced sodium conductance are more pronounced in NUA tissue, and b) that the resulting increase in dispersion may provoke arrhythmia by local differences in APD [1].

High impact information on SYNE2

• Expression of dominant negative Nesprin-2 constructs and knockdown studies in COS7 cells revealed that the presence of Nesprin-2 at the nuclear envelope is necessary for the proper localization of emerin [2].
• Our data imply a scaffolding function of Nesprin-2 at the nuclear membrane and suggest a potential involvement of this multi-isomeric protein in human disease [2].
• Selective disruption of the lamin A/C network in COS7 cells, using a dominant negative lamin B mutant, resulted in the redistribution of Nesprin-2 [2].
• With the discovery of the actin-binding properties of Enaptin and the highly homologous Nuance, we define a family of proteins that integrate the cytoskeleton with the nucleoskeleton [3].
• In the place of exon 8, ERbeta4 has unique sequences arising from a region downstream of the ERbeta gene and upstream of the SYNE2 gene [4].

Biological context of SYNE2

• Mean action potential duration (APD) was increased under UA (287 ms. dispersion: 0.8 ms) when compared to NUA (285 ms, disp.: 3.2 ms) [1].
• Letter: Nuance of breast feeding [5].

Associations of SYNE2 with chemical compounds

• There was no difference in the participation of these factors as a causative mechanism for anginal attack between UA and NUA [6].

References