Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Gene Review:

FMO2 - flavin containing monooxygenase 2 (non...

Homo sapiens

Synonyms: Dimethylaniline oxidase 2, FMO 1B1, FMO 2, Pulmonary flavin-containing monooxygenase 2

Stange, D.E. et al., Henderson, M.C. et al., Krueger, S.K. et al., McCombie, R.R. et al.

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Disease relevance of FMO2

2. Located within the candidate gains on 1q are two genes, FMO2 and PTGS2, known to be overexpressed in ILC relative to invasive ductal carcinoma [1].

High impact information on FMO2

S-oxygenation of the thioether organophosphate insecticides phorate and disulfoton by human lung flavin-containing monooxygenase 2 [2].
Localization of human flavin-containing monooxygenase genes FMO2 and FMO5 to chromosome 1q [3].
These microsomes also demonstrated a heat-associated loss of activity similar to expressed hFMO2 [4].

References

High-resolution genomic profiling reveals association of chromosomal aberrations on 1q and 16p with histologic and genetic subgroups of invasive breast cancer. Stange, D.E., Radlwimmer, B., Schubert, F., Traub, F., Pich, A., Toedt, G., Mendrzyk, F., Lehmann, U., Eils, R., Kreipe, H., Lichter, P. Clin. Cancer Res. (2006) [Pubmed]
S-oxygenation of the thioether organophosphate insecticides phorate and disulfoton by human lung flavin-containing monooxygenase 2. Henderson, M.C., Krueger, S.K., Siddens, L.K., Stevens, J.F., Williams, D.E. Biochem. Pharmacol. (2004) [Pubmed]
Localization of human flavin-containing monooxygenase genes FMO2 and FMO5 to chromosome 1q. McCombie, R.R., Dolphin, C.T., Povey, S., Phillips, I.R., Shephard, E.A. Genomics (1996) [Pubmed]
Identification of active flavin-containing monooxygenase isoform 2 in human lung and characterization of expressed protein. Krueger, S.K., Martin, S.R., Yueh, M.F., Pereira, C.B., Williams, D.E. Drug Metab. Dispos. (2002) [Pubmed]

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FMO2	Bos taurus
FMO2	Canis lupus familiaris
Fmo2	Mus musculus
FMO2	Pan troglodytes
Fmo2	Rattus norvegicus
MGC89174	Xenopus (Silurana) tropicalis
LOC100489408	Xenopus (Silurana) tropicalis

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