The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review

Carcinoma, Ductal

Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of Carcinoma, Ductal


High impact information on Carcinoma, Ductal

  • Conversely, BRCA1 expression was reduced or undetectable in the majority of high-grade, ductal carcinomas, suggesting that absence of BRCA1 may contribute to the pathogenesis of a significant percentage of sporadic breast cancers [6].
  • IL-6 represents a well-characterized molecule that regulates both the proliferation and junction-forming ability of breast ductal carcinoma cells [7].
  • The loss of CRBP expression was as frequent in ductal carcinoma in situ (six [27%] of 22) as in invasive lesions (six [22%] of 27), suggesting that it is a relatively early event in carcinogenesis and not associated with patient age, tumor grade, and expression of steroid receptors or c-Myc [8].
  • METHODS: Serial sections cut from 12 formalin-fixed, paraffin-embedded, p53-positive invasive ductal carcinomas of the breast were stored on slides at room temperature or at 4 degrees C, with or without an additional paraffin coating, for 2, 4, 8, or 12 weeks [9].
  • Of 7 cell lines derived from ductal carcinomas, 5 were stimulated by prolactin [10].

Chemical compound and disease context of Carcinoma, Ductal


Biological context of Carcinoma, Ductal


Anatomical context of Carcinoma, Ductal


Gene context of Carcinoma, Ductal


Analytical, diagnostic and therapeutic context of Carcinoma, Ductal


  1. Overexpression of cyclin D mRNA distinguishes invasive and in situ breast carcinomas from non-malignant lesions. Weinstat-Saslow, D., Merino, M.J., Manrow, R.E., Lawrence, J.A., Bluth, R.F., Wittenbel, K.D., Simpson, J.F., Page, D.L., Steeg, P.S. Nat. Med. (1995) [Pubmed]
  2. Randomized trial of fenretinide to prevent second breast malignancy in women with early breast cancer. Veronesi, U., De Palo, G., Marubini, E., Costa, A., Formelli, F., Mariani, L., Decensi, A., Camerini, T., Del Turco, M.R., Di Mauro, M.G., Muraca, M.G., Del Vecchio, M., Pinto, C., D'Aiuto, G., Boni, C., Campa, T., Magni, A., Miceli, R., Perloff, M., Malone, W.F., Sporn, M.B. J. Natl. Cancer Inst. (1999) [Pubmed]
  3. Activated signal transducer and activator of transcription 3 (STAT3) supports the malignant phenotype of human pancreatic cancer. Scholz, A., Heinze, S., Detjen, K.M., Peters, M., Welzel, M., Hauff, P., Schirner, M., Wiedenmann, B., Rosewicz, S. Gastroenterology (2003) [Pubmed]
  4. Matrix metalloproteinase 26 proteolysis of the NH2-terminal domain of the estrogen receptor beta correlates with the survival of breast cancer patients. Savinov, A.Y., Remacle, A.G., Golubkov, V.S., Krajewska, M., Kennedy, S., Duffy, M.J., Rozanov, D.V., Krajewski, S., Strongin, A.Y. Cancer Res. (2006) [Pubmed]
  5. Antitumor efficacy of PD115934 (NSC 366140) against solid tumors of mice. LoRusso, P., Wozniak, A.J., Polin, L., Capps, D., Leopold, W.R., Werbel, L.M., Biernat, L., Dan, M.E., Corbett, T.H. Cancer Res. (1990) [Pubmed]
  6. Localization of human BRCA1 and its loss in high-grade, non-inherited breast carcinomas. Wilson, C.A., Ramos, L., Villaseñor, M.R., Anders, K.H., Press, M.F., Clarke, K., Karlan, B., Chen, J.J., Scully, R., Livingston, D., Zuch, R.H., Kanter, M.H., Cohen, S., Calzone, F.J., Slamon, D.J. Nat. Genet. (1999) [Pubmed]
  7. Interleukin 6 decreases cell-cell association and increases motility of ductal breast carcinoma cells. Tamm, I., Cardinale, I., Krueger, J., Murphy, J.S., May, L.T., Sehgal, P.B. J. Exp. Med. (1989) [Pubmed]
  8. Cellular retinol-binding protein expression and breast cancer. Kuppumbatti, Y.S., Bleiweiss, I.J., Mandeli, J.P., Waxman, S., Mira-Y-Lopez, R. J. Natl. Cancer Inst. (2000) [Pubmed]
  9. Loss of tumor marker-immunostaining intensity on stored paraffin slides of breast cancer. Jacobs, T.W., Prioleau, J.E., Stillman, I.E., Schnitt, S.J. J. Natl. Cancer Inst. (1996) [Pubmed]
  10. In vitro growth promotion of human mammary carcinoma cells by steroid hormones, tamoxifen, and prolactin. Simon, W.E., Albrecht, M., Trams, G., Dietel, M., Hölzel, F. J. Natl. Cancer Inst. (1984) [Pubmed]
  11. Loss of Wnt-5a protein is associated with early relapse in invasive ductal breast carcinomas. Jönsson, M., Dejmek, J., Bendahl, P.O., Andersson, T. Cancer Res. (2002) [Pubmed]
  12. Suppression of 7,12-dimethylbenz(a)anthracene-induced mammary carcinogenesis in rats by resveratrol: role of nuclear factor-kappaB, cyclooxygenase 2, and matrix metalloprotease 9. Banerjee, S., Bueso-Ramos, C., Aggarwal, B.B. Cancer Res. (2002) [Pubmed]
  13. 2-difluoromethylornithine and dehydroepiandrosterone inhibit mammary tumor progression but not mammary or prostate tumor initiation in C3(1)/SV40 T/t-antigen transgenic mice. Green, J.E., Shibata, M.A., Shibata, E., Moon, R.C., Anver, M.R., Kelloff, G., Lubet, R. Cancer Res. (2001) [Pubmed]
  14. A new approach for induction of pancreatic neoplasms. Pour, P., Krüger, F.W., Althoff, J., Cardesa, A., Mohr, U. Cancer Res. (1975) [Pubmed]
  15. HER2/neu-induced mammary tumorigenesis and angiogenesis are reduced in cyclooxygenase-2 knockout mice. Howe, L.R., Chang, S.H., Tolle, K.C., Dillon, R., Young, L.J., Cardiff, R.D., Newman, R.A., Yang, P., Thaler, H.T., Muller, W.J., Hudis, C., Brown, A.M., Hla, T., Subbaramaiah, K., Dannenberg, A.J. Cancer Res. (2005) [Pubmed]
  16. Prognostic value of cytological grading of fine-needle aspirates from breast carcinomas. Robinson, I.A., McKee, G., Nicholson, A., D'Arcy, J., Jackson, P.A., Cook, M.G., Kissin, M.W. Lancet (1994) [Pubmed]
  17. Array comparative genomic hybridization analysis of genomic alterations in breast cancer subtypes. Loo, L.W., Grove, D.I., Williams, E.M., Neal, C.L., Cousens, L.A., Schubert, E.L., Holcomb, I.N., Massa, H.F., Glogovac, J., Li, C.I., Malone, K.E., Daling, J.R., Delrow, J.J., Trask, B.J., Hsu, L., Porter, P.L. Cancer Res. (2004) [Pubmed]
  18. Motility related protein 1 (MRP-1/CD9) expression: inverse correlation with metastases in breast cancer. Miyake, M., Nakano, K., Ieki, Y., Adachi, M., Huang, C.L., Itoi, S., Koh, T., Taki, T. Cancer Res. (1995) [Pubmed]
  19. CD44 isoform expression follows two alternative splicing pathways in breast tissue. Roca, X., Mate, J.L., Ariza, A., Muñoz-Mármol, A.M., von Uexküll-Güldeband, C., Pellicer, I., Navas-Palacios, J.J., Isamat, M. Am. J. Pathol. (1998) [Pubmed]
  20. Detection of RASSF1A aberrant promoter hypermethylation in sputum from chronic smokers and ductal carcinoma in situ from breast cancer patients. Honorio, S., Agathanggelou, A., Schuermann, M., Pankow, W., Viacava, P., Maher, E.R., Latif, F. Oncogene (2003) [Pubmed]
  21. Tumor suppressor activity of the gene encoding mammary-derived growth inhibitor. Huynh, H.T., Larsson, C., Narod, S., Pollak, M. Cancer Res. (1995) [Pubmed]
  22. Differential expression of keratins 13 and 16 in normal epithelium, benign lesions, and ductal carcinomas of the human breast determined by the monoclonal antibody Ks8.12. Pellegrino, M.B., Asch, B.B., Connolly, J.L., Asch, H.L. Cancer Res. (1988) [Pubmed]
  23. Deficiency of connexin43 gap junctions is an independent marker for breast tumors. Laird, D.W., Fistouris, P., Batist, G., Alpert, L., Huynh, H.T., Carystinos, G.D., Alaoui-Jamali, M.A. Cancer Res. (1999) [Pubmed]
  24. Expression of thrombospondin (TSP1) and its receptors (CD36 and CD51) in normal, hyperplastic, and neoplastic human breast. Clezardin, P., Frappart, L., Clerget, M., Pechoux, C., Delmas, P.D. Cancer Res. (1993) [Pubmed]
  25. Medullary carcinoma is associated with expression of intercellular adhesion molecule-1. Implication to its morphology and its clinical behavior. Bacus, S.S., Zelnick, C.R., Chin, D.M., Yarden, Y., Kaminsky, D.B., Bennington, J., Wen, D., Marcus, J.N., Page, D.L. Am. J. Pathol. (1994) [Pubmed]
  26. Psoriasin interacts with Jab1 and influences breast cancer progression. Emberley, E.D., Niu, Y., Leygue, E., Tomes, L., Gietz, R.D., Murphy, L.C., Watson, P.H. Cancer Res. (2003) [Pubmed]
  27. Identification of a novel breast- and salivary gland-specific, mucin-like gene strongly expressed in normal and tumor human mammary epithelium. Miksicek, R.J., Myal, Y., Watson, P.H., Walker, C., Murphy, L.C., Leygue, E. Cancer Res. (2002) [Pubmed]
  28. Endometase/matrilysin-2 in human breast ductal carcinoma in situ and its inhibition by tissue inhibitors of metalloproteinases-2 and -4: a putative role in the initiation of breast cancer invasion. Zhao, Y.G., Xiao, A.Z., Park, H.I., Newcomer, R.G., Yan, M., Man, Y.G., Heffelfinger, S.C., Sang, Q.X. Cancer Res. (2004) [Pubmed]
  29. Estrogen sulfotransferase and steroid sulfatase in human breast carcinoma. Suzuki, T., Nakata, T., Miki, Y., Kaneko, C., Moriya, T., Ishida, T., Akinaga, S., Hirakawa, H., Kimura, M., Sasano, H. Cancer Res. (2003) [Pubmed]
  30. The centrosomal kinase Nek2 displays elevated levels of protein expression in human breast cancer. Hayward, D.G., Clarke, R.B., Faragher, A.J., Pillai, M.R., Hagan, I.M., Fry, A.M. Cancer Res. (2004) [Pubmed]
  31. Motility-related protein-1 (MRP-1/CD9) reduction as a factor of poor prognosis in breast cancer. Miyake, M., Nakano, K., Itoi, S.I., Koh, T., Taki, T. Cancer Res. (1996) [Pubmed]
  32. Differential expression of psoriasin messenger RNA between in situ and invasive human breast carcinoma. Leygue, E., Snell, L., Hiller, T., Dotzlaw, H., Hole, K., Murphy, L.C., Watson, P.H. Cancer Res. (1996) [Pubmed]
  33. Chromogranin A and B gene expression in carcinomas of the breast. Correlation of immunocytochemical, immunoblot, and hybridization analyses. Pagani, A., Papotti, M., Höfler, H., Weiler, R., Winkler, H., Bussolati, G. Am. J. Pathol. (1990) [Pubmed]
  34. National surgical adjuvant breast and bowel project update: prevention trials and endocrine therapy of ductal carcinoma in situ. Vogel, V.G., Costantino, J.P., Wickerham, D.L., Cronin, W.M. Clin. Cancer Res. (2003) [Pubmed]
WikiGenes - Universities