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Gene Review

LPHN3  -  latrophilin 3

Homo sapiens

Synonyms: CIRL-3, CIRL3, Calcium-independent alpha-latrotoxin receptor 3, KIAA0768, LEC3, ...
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High impact information on LPHN3

  • We have mutagenized Lec3 CHO cells and isolated six mutants (termed C2m) deficient in the cell surface expression of polysialic acid (PSA) [1].

Associations of LPHN3 with chemical compounds

  • Lec3 CHO cell mutants are deficient in epimerase activity, due to a defect in the gene that encodes a bifunctional UDP-GlcNAc 2-epimerase/ManNAc kinase (GNE) [1].

Analytical, diagnostic and therapeutic context of LPHN3

  • In addition to EST profiling, RT- PCR was used to detect transcripts of the olfactomedin-domain proteins latrotoxin receptor Lec3 and optimedin in the TM [2].


  1. Isolation of New CHO Cell Mutants Defective in CMP-Sialic Acid Biosynthesis and Transport. Shin, D.J., Kang, J.Y., Kim, Y.U., Yoon, J.S., Choy, H.E., Maeda, Y., Kinoshita, T., Hong, Y. Mol. Cells (2006) [Pubmed]
  2. Gene expression profile of the human trabecular meshwork: NEIBank sequence tag analysis. Tomarev, S.I., Wistow, G., Raymond, V., Dubois, S., Malyukova, I. Invest. Ophthalmol. Vis. Sci. (2003) [Pubmed]
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