The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)



Gene Review

OLFM3  -  olfactomedin 3

Homo sapiens

Synonyms: NOE3, NOELIN3, Noelin-3, OPTIMEDIN, Olfactomedin-3, ...
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of OLFM3


High impact information on OLFM3

  • In the human eye, optimedin is expressed in the retina and the trabecular meshwork [2].
  • However, unlike noelin, rat optimedin is also highly expressed in the epithelial cells of the iris and the ciliary body in close proximity to the sites of Myoc expression [2].
  • Here we describe the identification of a novel olfactomedin-related gene, named optimedin, located on chromosome 1p21 in humans [2].
  • The proximal promoter of the Optimedin A variant contains a putative Pax6 binding site in position -86/-70 [3].
  • Pax6 regulation of Optimedin in the eye and brain may directly affect multiple developmental processes, including cell migration and axon growth [3].

Biological context of OLFM3


Anatomical context of OLFM3

  • To study possible effects of optimedin on the differentiation of neural cells, we produced stably transfected PC12 cell lines expressing optimedin under a tetracycline-inducible promoter [5].
  • We suggest that expression of optimedin stimulates the formation of adherent and tight junctions on the cell surface and this may play an important role in the differentiation of the brain and retina through the modulation of cytoskeleton organization, cell-cell adhesion and migration [5].
  • Expression of optimedin also changed the organization of the actin cytoskeleton and inhibited neurite outgrowth in NGF-stimulated PC12 cells [5].

Regulatory relationships of OLFM3


Other interactions of OLFM3


  1. Gene expression profile of the rat eye iridocorneal angle: NEIBank expressed sequence tag analysis. Ahmed, F., Torrado, M., Zinovieva, R.D., Senatorov, V.V., Wistow, G., Tomarev, S.I. Invest. Ophthalmol. Vis. Sci. (2004) [Pubmed]
  2. Optimedin: a novel olfactomedin-related protein that interacts with myocilin. Torrado, M., Trivedi, R., Zinovieva, R., Karavanova, I., Tomarev, S.I. Hum. Mol. Genet. (2002) [Pubmed]
  3. The Optimedin gene is a downstream target of Pax6. Grinchuk, O., Kozmik, Z., Wu, X., Tomarev, S. J. Biol. Chem. (2005) [Pubmed]
  4. Bioinformatic approaches for identification and characterization of olfactomedin related genes with a potential role in pathogenesis of ocular disorders. Mukhopadhyay, A., Talukdar, S., Bhattacharjee, A., Ray, K. Mol. Vis. (2004) [Pubmed]
  5. Optimedin induces expression of N-cadherin and stimulates aggregation of NGF-stimulated PC12 cells. Lee, H.S., Tomarev, S.I. Exp. Cell Res. (2007) [Pubmed]
  6. Gene expression profile of the human trabecular meshwork: NEIBank sequence tag analysis. Tomarev, S.I., Wistow, G., Raymond, V., Dubois, S., Malyukova, I. Invest. Ophthalmol. Vis. Sci. (2003) [Pubmed]
WikiGenes - Universities