Chemical Compound Review:
Uridine pyrophosphoacetylglucosamine [(2R,3R,4R,5S,6R)-3- acetamido-4,5...
Synonyms:
UPPAG, AC1LD8D9, 528-04-1, UDP-acetylglucosamine, UDP-N-acetyl-glucosamine, ...
- Crystal structure of the MurG:UDP-GlcNAc complex reveals common structural principles of a superfamily of glycosyltransferases. Hu, Y., Chen, L., Ha, S., Gross, B., Falcone, B., Walker, D., Mokhtarzadeh, M., Walker, S. Proc. Natl. Acad. Sci. U.S.A. (2003)
- Mutations in the human UDP-N-acetylglucosamine 2-epimerase gene define the disease sialuria and the allosteric site of the enzyme. Seppala, R., Lehto, V.P., Gahl, W.A. Am. J. Hum. Genet. (1999)
- Overexpression of core 2 N-acetylglycosaminyltransferase enhances cytokine actions and induces hypertrophic myocardium in transgenic mice. Koya, D., Dennis, J.W., Warren, C.E., Takahara, N., Schoen, F.J., Nishio, Y., Nakajima, T., Lipes, M.A., King, G.L. FASEB J. (1999)
- Incorporation of N-acetyl-D-glucosamine from UDP-N-acetyl-D-glucosamine by isolated membranes of Bacillus subtilis. Identification of undecaprenyl poly(N-acetylglucosaminyl pyrophosphate). Bettinger, G.E., Chatterjee, A.N., Young, F.E. J. Biol. Chem. (1977)
- A single bifunctional UDP-GlcNAc/Glc 4-epimerase supports the synthesis of three cell surface glycoconjugates in Campylobacter jejuni. Bernatchez, S., Szymanski, C.M., Ishiyama, N., Li, J., Jarrell, H.C., Lau, P.C., Berghuis, A.M., Young, N.M., Wakarchuk, W.W. J. Biol. Chem. (2005)
- Selection and characterization of eight phenotypically distinct lines of lectin-resistant Chinese hamster ovary cell. Stanley, P., Caillibot, V., Siminovitch, L. Cell (1975)
- A nutrient-sensing pathway regulates leptin gene expression in muscle and fat. Wang, J., Liu, R., Hawkins, M., Barzilai, N., Rossetti, L. Nature (1998)
- UDP-GlcNAc 2-epimerase: a regulator of cell surface sialylation. Keppler, O.T., Hinderlich, S., Langner, J., Schwartz-Albiez, R., Reutter, W., Pawlita, M. Science (1999)
- Role of the glucosamine pathway in fat-induced insulin resistance. Hawkins, M., Barzilai, N., Liu, R., Hu, M., Chen, W., Rossetti, L. J. Clin. Invest. (1997)
- In vivo glucosamine infusion induces insulin resistance in normoglycemic but not in hyperglycemic conscious rats. Rossetti, L., Hawkins, M., Chen, W., Gindi, J., Barzilai, N. J. Clin. Invest. (1995)
- Regulation of UDP-3-O-[R-3-hydroxymyristoyl]-N-acetylglucosamine deacetylase in Escherichia coli. The second enzymatic step of lipid a biosynthesis. Sorensen, P.G., Lutkenhaus, J., Young, K., Eveland, S.S., Anderson, M.S., Raetz, C.R. J. Biol. Chem. (1996)
- Sialic acid metabolism in sialuria fibroblasts. Seppala, R., Tietze, F., Krasnewich, D., Weiss, P., Ashwell, G., Barsh, G., Thomas, G.H., Packman, S., Gahl, W.A. J. Biol. Chem. (1991)
- Enzymatic synthesis of lipid A molecules with four amide-linked acyl chains. LpxA acyltransferases selective for an analog of UDP-N-acetylglucosamine in which an amine replaces the 3"-hydroxyl group. Sweet, C.R., Williams, A.H., Karbarz, M.J., Werts, C., Kalb, S.R., Cotter, R.J., Raetz, C.R. J. Biol. Chem. (2004)
- Crystal structure of Streptococcus pneumoniae N-acetylglucosamine-1-phosphate uridyltransferase bound to acetyl-coenzyme A reveals a novel active site architecture. Sulzenbacher, G., Gal, L., Peneff, C., Fassy, F., Bourne, Y. J. Biol. Chem. (2001)
- The O-antigen gene cluster of Escherichia coli O55:H7 and identification of a new UDP-GlcNAc C4 epimerase gene. Wang, L., Huskic, S., Cisterne, A., Rothemund, D., Reeves, P.R. J. Bacteriol. (2002)
- Transport of newly synthesized vesicular stomatitis viral glycoprotein to purified Golgi membranes. Rothman, J.E., Fries, E. J. Cell Biol. (1981)
- Co-ordinated regulation of amino sugar biosynthesis and degradation: the NagC repressor acts as both an activator and a repressor for the transcription of the glmUS operon and requires two separated NagC binding sites. Plumbridge, J. EMBO J. (1995)
- Decreased UDP-GlcNAc levels abrogate proliferation control in EMeg32-deficient cells. Boehmelt, G., Wakeham, A., Elia, A., Sasaki, T., Plyte, S., Potter, J., Yang, Y., Tsang, E., Ruland, J., Iscove, N.N., Dennis, J.W., Mak, T.W. EMBO J. (2000)
- Altered glycan-dependent signaling induces insulin resistance and hyperleptinemia. McClain, D.A., Lubas, W.A., Cooksey, R.C., Hazel, M., Parker, G.J., Love, D.C., Hanover, J.A. Proc. Natl. Acad. Sci. U.S.A. (2002)
- Mammalian Golgi apparatus UDP-N-acetylglucosamine transporter: molecular cloning by phenotypic correction of a yeast mutant. Guillen, E., Abeijon, C., Hirschberg, C.B. Proc. Natl. Acad. Sci. U.S.A. (1998)
- Early lipid intermediates in glycosyl-phosphatidylinositol anchor assembly are synthesized in the ER and located in the cytoplasmic leaflet of the ER membrane bilayer. Vidugiriene, J., Menon, A.K. J. Cell Biol. (1993)
- Sialylation is essential for early development in mice. Schwarzkopf, M., Knobeloch, K.P., Rohde, E., Hinderlich, S., Wiechens, N., Lucka, L., Horak, I., Reutter, W., Horstkorte, R. Proc. Natl. Acad. Sci. U.S.A. (2002)
- Inositol acylation of a potential glycosyl phosphoinositol anchor precursor from yeast requires acyl coenzyme A. Costello, L.C., Orlean, P. J. Biol. Chem. (1992)
- X-ray crystal structure of rabbit N-acetylglucosaminyltransferase I: catalytic mechanism and a new protein superfamily. Unligil, U.M., Zhou, S., Yuwaraj, S., Sarkar, M., Schachter, H., Rini, J.M. EMBO J. (2000)
- Molecular cloning of the Golgi apparatus uridine diphosphate-N-acetylglucosamine transporter from Kluyveromyces lactis. Abeijon, C., Robbins, P.W., Hirschberg, C.B. Proc. Natl. Acad. Sci. U.S.A. (1996)
- Bovine UDP-N-acetylglucosamine:lysosomal-enzyme N-acetylglucosamine-1-phosphotransferase. II. Enzymatic characterization and identification of the catalytic subunit. Bao, M., Elmendorf, B.J., Booth, J.L., Drake, R.R., Canfield, W.M. J. Biol. Chem. (1996)
- Estrogen-induced changes in chick oviduct membrane glycoproteins. DeRosa, P.A., Lucas, J.J. J. Biol. Chem. (1982)
- Biosynthesis of lipid-linked oligosaccharides in Saccharomyces cerevisiae: Alg13p and Alg14p form a complex required for the formation of GlcNAc(2)-PP-dolichol. Bickel, T., Lehle, L., Schwarz, M., Aebi, M., Jakob, C.A. J. Biol. Chem. (2005)
- Isolation of null alleles of the Caenorhabditis elegans gly-12, gly-13 and gly-14 genes, all of which encode UDP-GlcNAc: alpha-3-D-mannoside beta1,2-N-acetylglucosaminyltransferase I activity. Chen, S., Spence, A.M., Schachter, H. Biochimie (2003)
- Characterization of Yeast Yea4p, a uridine diphosphate-N-acetylglucosamine transporter localized in the endoplasmic reticulum and required for chitin synthesis. Roy, S.K., Chiba, Y., Takeuchi, M., Jigami, Y. J. Biol. Chem. (2000)
- The eukaryotic UDP-N-acetylglucosamine pyrophosphorylases. Gene cloning, protein expression, and catalytic mechanism. Mio, T., Yabe, T., Arisawa, M., Yamada-Okabe, H. J. Biol. Chem. (1998)
- Phosphorylation of mouse glutamine-fructose-6-phosphate amidotransferase 2 (GFAT2) by cAMP-dependent protein kinase increases the enzyme activity. Hu, Y., Riesland, L., Paterson, A.J., Kudlow, J.E. J. Biol. Chem. (2004)
- A bifunctional enzyme catalyzes the first two steps in N-acetylneuraminic acid biosynthesis of rat liver. Purification and characterization of UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase. Hinderlich, S., Stäsche, R., Zeitler, R., Reutter, W. J. Biol. Chem. (1997)
- Biosynthesis of lipid A precursors in Escherichia coli. A cytoplasmic acyltransferase that converts UDP-N-acetylglucosamine to UDP-3-O-(R-3-hydroxymyristoyl)-N-acetylglucosamine. Anderson, M.S., Raetz, C.R. J. Biol. Chem. (1987)
- Circular dichroic spectroscopy of N-acetylglucosaminyltransferase V and its substrate interactions. Zhang, N., Peng, K.C., Chen, L., Puett, D., Pierce, M. J. Biol. Chem. (1997)
- FlaA1, a new bifunctional UDP-GlcNAc C6 Dehydratase/ C4 reductase from Helicobacter pylori. Creuzenet, C., Schur, M.J., Li, J., Wakarchuk, W.W., Lam, J.S. J. Biol. Chem. (2000)