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Gene Review

ZDHHC17  -  zinc finger, DHHC-type containing 17

Homo sapiens

Synonyms: DHHC-17, HIP-14, HIP-3, HIP14, HIP3, ...
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High impact information on ZDHHC17

  • The palmitoylation and distribution of htt are regulated by the palmitoyl transferase huntingtin interacting protein 14 (HIP14) [1].
  • Downregulation of HIP14 in mouse neurons expressing wild-type and mutant htt increases inclusion formation, whereas overexpression of HIP14 substantially reduces inclusions [1].
  • Using the yeast two-hybrid system, we have isolated a novel htt interacting protein, HIP14 [2].
  • Expression of human HIP14 results in rescue of the temperature-sensitive lethality in akr1 Delta yeast cells and, furthermore, restores their defect in endocytosis, demonstrating a role for HIP14 in intracellular trafficking [2].

Biological context of ZDHHC17


Associations of ZDHHC17 with chemical compounds

  • These findings define HIP14 as a mammalian palmitoyl transferase involved in the palmitoylation and trafficking of multiple neuronal proteins [3].


  1. Palmitoylation of huntingtin by HIP14 is essential for its trafficking and function. Yanai, A., Huang, K., Kang, R., Singaraja, R.R., Arstikaitis, P., Gan, L., Orban, P.C., Mullard, A., Cowan, C.M., Raymond, L.A., Drisdel, R.C., Green, W.N., Ravikumar, B., Rubinsztein, D.C., El-Husseini, A., Hayden, M.R. Nat. Neurosci. (2006) [Pubmed]
  2. HIP14, a novel ankyrin domain-containing protein, links huntingtin to intracellular trafficking and endocytosis. Singaraja, R.R., Hadano, S., Metzler, M., Givan, S., Wellington, C.L., Warby, S., Yanai, A., Gutekunst, C.A., Leavitt, B.R., Yi, H., Fichter, K., Gan, L., McCutcheon, K., Chopra, V., Michel, J., Hersch, S.M., Ikeda, J.E., Hayden, M.R. Hum. Mol. Genet. (2002) [Pubmed]
  3. Huntingtin-interacting protein HIP14 is a palmitoyl transferase involved in palmitoylation and trafficking of multiple neuronal proteins. Huang, K., Yanai, A., Kang, R., Arstikaitis, P., Singaraja, R.R., Metzler, M., Mullard, A., Haigh, B., Gauthier-Campbell, C., Gutekunst, C.A., Hayden, M.R., El-Husseini, A. Neuron (2004) [Pubmed]
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