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Gene Review

TIP1  -  S-acyltransferase TIP1

Arabidopsis thaliana

Synonyms: F5O24.240, F5O24_240, TIP GROWTH DEFECTIVE 1
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Disease relevance of TIP1


High impact information on TIP1

  • We have identified TIP1 by map-based cloning and complementation of the mutant phenotype [2].
  • TIP GROWTH DEFECTIVE1 (TIP1) of Arabidopsis thaliana affects cell growth throughout the plant and has a particularly strong effect on root hair growth [2].
  • We show that TIP1 binds the acyl group palmitate, that it can rescue the morphological, temperature sensitivity, and yeast casein kinase2 localization defects of the yeast S-acyl transferase mutant akr1Delta, and that inhibition of acylation in wild-type Arabidopsis roots reproduces the Tip1- mutant phenotype [2].
  • Two homologues of TIP1 in yeast (Saccharomyces cerevisiae) and human (Homo sapiens) have been shown to have S-acyl transferase (also known as palmitoyl transferase) activity [2].
  • For example, we show that TIP1 and RHD3 are required much earlier in hair formation than previous studies have suggested [3].

Biological context of TIP1

  • (iii) A sudden increment of several members of PIP2 and TIP1 subfamilies might be related to cell death [4].

Anatomical context of TIP1


Associations of TIP1 with chemical compounds

  • The use of antipeptide antibodies that cross-reacted with isoforms of specific aquaporin subclasses revealed that the abundance of PIP1s decreased by 40% as early as 30 min after salt exposure, whereas PIP2 and TIP1 homologs showed a 20% to 40% decrease in abundance after 6 h of treatment [5].

Other interactions of TIP1


  1. Arabidopsis tonoplast proteins TIP1 and TIP2 interact with the cucumber mosaic virus 1a replication protein. Kim, M.J., Kim, H.R., Paek, K.H. J. Gen. Virol. (2006) [Pubmed]
  2. The TIP GROWTH DEFECTIVE1 S-acyl transferase regulates plant cell growth in Arabidopsis. Hemsley, P.A., Kemp, A.C., Grierson, C.S. Plant Cell (2005) [Pubmed]
  3. Genetic interactions during root hair morphogenesis in Arabidopsis. Parker, J.S., Cavell, A.C., Dolan, L., Roberts, K., Grierson, C.S. Plant Cell (2000) [Pubmed]
  4. Immunochemical analysis of aquaporin isoforms in Arabidopsis suspension-cultured cells. Kobae, Y., Mizutani, M., Segami, S., Maeshima, M. Biosci. Biotechnol. Biochem. (2006) [Pubmed]
  5. Early effects of salinity on water transport in Arabidopsis roots. Molecular and cellular features of aquaporin expression. Boursiac, Y., Chen, S., Luu, D.T., Sorieul, M., van den Dries, N., Maurel, C. Plant Physiol. (2005) [Pubmed]
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