Disease relevance of TIP1

• Arabidopsis tonoplast proteins TIP1 and TIP2 interact with the cucumber mosaic virus 1a replication protein [1].

High impact information on TIP1

• We have identified TIP1 by map-based cloning and complementation of the mutant phenotype [2].
• TIP GROWTH DEFECTIVE1 (TIP1) of Arabidopsis thaliana affects cell growth throughout the plant and has a particularly strong effect on root hair growth [2].
• We show that TIP1 binds the acyl group palmitate, that it can rescue the morphological, temperature sensitivity, and yeast casein kinase2 localization defects of the yeast S-acyl transferase mutant akr1Delta, and that inhibition of acylation in wild-type Arabidopsis roots reproduces the Tip1- mutant phenotype [2].
• Two homologues of TIP1 in yeast (Saccharomyces cerevisiae) and human (Homo sapiens) have been shown to have S-acyl transferase (also known as palmitoyl transferase) activity [2].
• For example, we show that TIP1 and RHD3 are required much earlier in hair formation than previous studies have suggested [3].

Biological context of TIP1

• (iii) A sudden increment of several members of PIP2 and TIP1 subfamilies might be related to cell death [4].

Anatomical context of TIP1

• Additionally, CMV 1a co-localized with TIP1 and TIP2 in transfected Arabidopsis protoplasts [1].

Associations of TIP1 with chemical compounds

• The use of antipeptide antibodies that cross-reacted with isoforms of specific aquaporin subclasses revealed that the abundance of PIP1s decreased by 40% as early as 30 min after salt exposure, whereas PIP2 and TIP1 homologs showed a 20% to 40% decrease in abundance after 6 h of treatment [5].

Other interactions of TIP1

• The interaction of CMV 1a with the TIP1 and TIP2 proteins was confirmed via co-immunoprecipitation assays [1].

References