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Gene Review

SEZ6L  -  seizure related 6 homolog (mouse)-like

Homo sapiens

Synonyms: KIAA0927, Seizure 6-like protein, UNQ2542/PRO6094
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Disease relevance of SEZ6L

  • Identification of a 428-kb homozygously deleted region disrupting the SEZ6L gene at 22q12.1 in a lung cancer cell line [1].
  • The results of these studies representing 906 cases compared with 811 controls indicate a role of the SEZ6L Met430Ile polymorphic variant in increasing lung cancer risk [2].

High impact information on SEZ6L

  • SEZ6L expression was detected in a variety of human tissues, including lung, while its expression was detected in 14 (30%) of 46 lung cancer cell lines examined [1].
  • The deleted region contained the SEZ6L (Seizure 6-like) gene, whose structure had been partially determined by the chromosome 22 sequencing project [1].
  • The deduced SEZ6L protein was a transmembrane protein of 1024 amino acids with multiple domains involved in protein - protein interaction and signal transduction [1].

Analytical, diagnostic and therapeutic context of SEZ6L

  • We determined the full length cDNA sequence for the SEZ6L gene based on the genomic sequence for the SEZ6L locus using the GENSCAN program and the RT - PCR method [1].


  1. Identification of a 428-kb homozygously deleted region disrupting the SEZ6L gene at 22q12.1 in a lung cancer cell line. Nishioka, M., Kohno, T., Takahashi, M., Niki, T., Yamada, T., Sone, S., Yokota, J. Oncogene (2000) [Pubmed]
  2. Seizure 6-like (SEZ6L) gene and risk for lung cancer. Gorlov, I.P., Meyer, P., Liloglou, T., Myles, J., Boettger, M.B., Cassidy, A., Girard, L., Minna, J.D., Fischer, R., Duffy, S., Spitz, M.R., Haeussinger, K., Kammerer, S., Cantor, C., Dierkesmann, R., Field, J.K., Amos, C.I. Cancer Res. (2007) [Pubmed]
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