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Gene Review: 

Acaa1b  -  acetyl-Coenzyme A acyltransferase 1B

Mus musculus

Synonyms: 3-ketoacyl-CoA thiolase B, peroxisomal, Acaa1, Acetyl-CoA acyltransferase B, Beta-ketothiolase B, Peroxisomal 3-oxoacyl-CoA thiolase B, ...
 
 
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High impact information on Acaa1b

  • Hence, to better understand the cause of isolated human thiolase deficiency, we disrupted the catalytic site of the mouse thiolase B by homologous recombination in order to analyse the phenotype of these thiolase B-deficient mice [1].
  • Targeted disruption of the peroxisomal thiolase B gene in mouse: a new model to study disorders related to peroxisomal lipid metabolism [1].
  • In this regard, we showed that although PPARalpha binds to thiolase B gene promoter at -681 to -669, a better response is observed with hepatic nuclear factor 4 ("HNf-4") [2].
  • Thiolase A mRNA was mainly expressed in liver and intestine, while thiolase B mRNA essentially exhibited hepatic expression and weaker levels in kidney, intestine and white adipose tissue [3].

References

  1. Targeted disruption of the peroxisomal thiolase B gene in mouse: a new model to study disorders related to peroxisomal lipid metabolism. Chevillard, G., Clémencet, M.C., Latruffe, N., Nicolas-Francès, V. Biochimie (2004) [Pubmed]
  2. Peroxisome-proliferator-activated receptors as physiological sensors of fatty acid metabolism: molecular regulation in peroxisomes. Latruffe, N., Cherkaoui Malki, M., Nicolas-Frances, V., Jannin, B., Clemencet, M.C., Hansmannel, F., Passilly-Degrace, P., Berlot, J.P. Biochem. Soc. Trans. (2001) [Pubmed]
  3. Molecular cloning, gene structure and expression profile of two mouse peroxisomal 3-ketoacyl-CoA thiolase genes. Chevillard, G., Clémencet, M.C., Etienne, P., Martin, P., Pineau, T., Latruffe, N., Nicolas-Francès, V. BMC Biochem. (2004) [Pubmed]
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