Disease relevance of Acaa1a

• Thiolase A and B expressions in the other tissues such as brain or muscle were very low though these tissues were chiefly involved in peroxisomal disorders [1].

High impact information on Acaa1a

• The presence of macrophages in PTL appeared to have an inverse relationship to the in vivo protective effect [2].
• However, when lymphocytes isolated from tumor sites were assayed, it was found that there was no remarkable difference between lymphocytes from progressor tumors (PTL) and lymphocytes from regressor tumors (RTL) [2].
• They exhibit no detectable phenotype defects and no compensation, rather a slight decrease in other peroxisomal thiolase (thiolase A and SCPx) mRNAs, was found [3].
• Thiolase A mRNA was mainly expressed in liver and intestine, while thiolase B mRNA essentially exhibited hepatic expression and weaker levels in kidney, intestine and white adipose tissue [1].
• Moreover, thiolase A and B genes were differently induced in liver of mice treated with fenofibrate [1].

Biological context of Acaa1a

• Thiolase A and B cDNAs possess an open reading frame of 1272 nucleotides encoding a protein of 424 amino acids [1].
• Both thiolase A and B genes contain 12 exons and 11 introns [1].

Anatomical context of Acaa1a

• This is linked to a proceeding ossification, as is shown by the positive correlation of PTL with the size of the secondary ossification centre and number of capillaries [4].
• The regulation of haemopoiesis appears to be a normal function of bone marrow PTL [5].
• In contrast, the height of the various zones in the growth plate show a negative correlation with PTL [4].
• In normal mice increase in length of the tibia (PTL) is positively correlated with body length [4].
• Bone marrow Ig-Thy-1-SC-1- stem cells (precursors of T-lymphocytes, PTL, containing the SC-1 antigen) spontaneously secrete a humoral factor [5].

Associations of Acaa1a with chemical compounds

• The CSF and the suppressor factor are both also produced by cortisone-resistant radioresistant L3T4-Lyt-2-SC-1+ thymocytes (i.e. intrathymic PTL) [5].

Other interactions of Acaa1a

• Tissue-specific expression of two peroxisomal 3-ketoacyl-CoA thiolase genes in wild and PPAR alpha-null mice and induction by fenofibrate [6].

Analytical, diagnostic and therapeutic context of Acaa1a

• Molecular cloning, gene structure and expression profile of two mouse peroxisomal 3-ketoacyl-CoA thiolase genes [1].
• Nevertheless, when in vivo tumor transplantation experiments were performed, RTL were found to give protection against FBL-3 challenge whereas PTL consistently failed to do so [2].

References