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Gene Review

NTSR2  -  neurotensin receptor 2

Homo sapiens

Synonyms: Levocabastine-sensitive neurotensin receptor, NT-R-2, NTR2, Neurotensin receptor type 2
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High impact information on NTSR2

  • The constitutive activity of the ghrelin receptor and of neurotensin receptor 2 through the G(q), phospholipase C pathway was approximately 50% of their maximal capacity as determined through inositol phosphate accumulation [1].
  • NTta QTL on chromosomes 3, 7, and 8 coincide with QTL previously identified that impact NT peptide content and NTR2ta QTL on chromosome 2 and 12 coincide with genes previously associated with NTR2 receptor abundance [2].


  1. Common structural basis for constitutive activity of the ghrelin receptor family. Holst, B., Holliday, N.D., Bach, A., Elling, C.E., Cox, H.M., Schwartz, T.W. J. Biol. Chem. (2004) [Pubmed]
  2. Genetic analysis of the hypothalamic neurotensin system. Garlow, S.J., Boone, E., Kinkead, B., Nemeroff, C.B. Neuropsychopharmacology (2006) [Pubmed]
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